Results 91 to 100 of about 9,151,209 (331)
Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan +10 morewiley +1 more sourceConfidence in COVID-19 vaccine effectiveness and safety and its effect on vaccine uptake in Tanzania: A community-based cross-sectional study
Human Vaccines & Immunotherapeutics, 2023 COVID-19 is a major public health threat associated with increased disease burden, mortality, and economic loss to countries and communities. Safe and efficacious COVID-19 vaccines are key in halting and reversing the pandemic. Low confidence in vaccines Monica Mtei, Innocent B. Mboya, Melina Mgongo, Rachel Manongi, Caroline Amour, Julieth S. Bilakwate, Ahmed Y. Nyaki, James Ngocho, Norman Jonas, Amina Farah, Maryam Amour, Albino Kalolo, James T. Kengia, Florian Tinuga, Frida Ngalesoni, Abdalla H. Bakari, Fatimata B. Kirakoya, Awet Araya, Ntuli A. Kapologwe, Sia E. Msuya +19 moredoaj +1 more sourceOptimal Confidence Regions for the Multinomial Parameter
CoRR, 2020 Construction of tight confidence regions and intervals is central to statistical inference and decision making. This paper develops new theory showing minimum average volume confidence regions for categorical data. More precisely, consider an empirical distribution $\widehat{\boldsymbol{p}}$ generated from $n$ iid realizations of a random variable that Matthew L. Malloy, Ardhendu Tripathy, Robert D. Nowak +2 moreopenaire +2 more sourcesSubtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan +6 morewiley +1 more sourceGenetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova +25 morewiley +1 more sourceSearches for sterile neutrinos with the IceCube detector [PDF]
, 2016 The IceCube neutrino telescope at the South Pole has measured the atmospheric muon neutrino spectrum as a function of zenith angle and energy in the approximate 320 GeV to 20 TeV range, to search for the oscillation signatures of light sterile neutrinos. Aartsen, M. G., Abraham, K., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Archinger, M., Argüelles, C., Arlen, T. C., Auffenberg, J., Axani, S., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Becker Tjus, J., Becker, K.-H., BenZvi, S., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Boersma, D. J., Bohm, C., Bos, F., Bose, D., Botner, O., Braun, J., Brayeur, L., Bretz, H.-P., Burgman, A., Börner, M., Böser, S., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Clark, K., Classen, L., Coenders, S., Collin, G. H., Conrad, J. M., Cowen, D. F., Cruz Silva, A. H., Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., de Vries, K. D., de Wasseige, G., de With, M., del Pino Rosendo, E., Dembinski, H., Desiati, P., DeYoung, T., di Lorenzo, V., Dujmovic, H., Dumm, J. P., Dunkman, M., Díaz-Vélez, J. C., Eberhardt, B., Ehrhardt, T., Eichmann, B., Euler, S., Evenson, P. A., Fahey, S., Fazely, A. R., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Flis, S., Fuchs, T., Fösig, C.-C., Gaior, R., Gaisser, T. K., Gallagher, J., Gerhardt, L., Ghorbani, K., Giang, W., Gladstone, L., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Grant, D., Griffith, Z., Góra, D., Haj Ismail, A., Hallgren, A., Halzen, F., Hansen, E., Hanson, K., Hebecker, D., Heereman, D., Helbing, K., Hellauer, R., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Holzapfel, K., Homeier, A., Hoshina, K., Huang, F., Huber, M., Huelsnitz, W., Hultqvist, K., IceCube Collaboration, In, S., Ishihara, A., Jacobi, E., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Jurkovic, M., Kappes, A., Karg, T., Karle, A., Katz, U., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kim, M., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Kohnen, G., Koirala, R., Kolanoski, H., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Kroll, M., Krückl, G., Krüger, C., Kunnen, J., Kunwar, S., Kurahashi, N., Kuwabara, T., Köpke, L., Labare, M., Lanfranchi, J. L., Larson, M. J., Lennarz, D., Lesiak-Bzdak, M., Leuermann, M., Lu, L., Lünemann, J., Madsen, J., Maggi, G., Mahn, K. B. M., Mancina, S., Mandelartz, M., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Meier, M., Meli, A., Menne, T., Merino, G., Meures, T., Miarecki, S., Middell, E., Mohrmann, L., Montaruli, T., Moulai, M., Nahnhauer, R., Naumann, U., Neer, G., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Olivas, A., Omairat, A., O’Murchadha, A., Palczewski, T., Pandya, H., Pankova, D. V., Pepper, J. A., Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pérez de los Heros, C., Quinnan, M., Raab, C., Rameez, M., Rawlins, K., Relich, M., Resconi, E., Rhode, W., Richman, M., Riedel, B., Robertson, S., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Sabbatini, L., Salvado, J., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Sarkar, S., Satalecka, K., Schlunder, P., Schmidt, T., Schöneberg, S., Schönwald, A., Seckel, D., Seunarine, S., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stasik, A., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Ström, R., Stößl, A., Sullivan, G. W., Sutherland, M., Taavola, H., Taboada, I., Tatar, J., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Toscano, S., Tosi, D., Tselengidou, M., Turcati, A., Unger, E., Usner, M., Vallecorsa, S., van Eijndhoven, N., van Rossem, M., van Santen, J., Vandenbroucke, J., Vanheule, S., Veenkamp, J., Voge, M., Vraeghe, M., Walck, C., Wallace, A., Wandkowsky, N., Weaver, Ch., Wendt, C., Westerhoff, S., Whelan, B. J., Wiebe, K., Wille, L., Williams, D. R., Wills, L., Wissing, H., Wolf, M., Wood, T. R., Woolsey, E., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Zoll, M. +300 morecore +4 more sourcesTargeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa +6 morewiley +1 more sourceImproved Constraints on D0-D0bar Mixing in D0 -> K+ pi- Decays from the
Belle Detector
, 2006 We report the results of a search for D0-D0bar mixing in D0 -> K+ pi- decays
based on 400 fb^{-1} of data accumulated by the Belle detector at KEKB. Both
assuming CP conservation and allowing for CP violation, we fit the decay-time
distribution for the ...A. Bay, A. Bondar, A. Bozek, A. Chen, A. Chuvikov, A. Drutskoy, A. Go, A. Gorišek, A. Ishikawa, A. J. Schwartz, A. Kuzmin, A. M. Bakich, A. Sokolov, A. Somov, A. Yamaguchi, B. D. Yabsley, B. G. Cheon, B. Golob, B. Shwartz, C. C. Kuo, C. C. Wang, C. C. Zhang, C. H. Wang, C. Schwanda, C. W. Park, D. Anipko, D. Liventsev, D. Mohapatra, D. Zürcher, E. Won, F. Mandl, F. Takasaki, G. Gokhroo, G. Leder, G. N. Taylor, G. Varner, H. Aihara, H. C. Ha, H. Hayashii, H. Ishino, H. J. Kim, H. Kawai, H. Kichimi, H. Miyake, H. Miyata, H. Ozaki, H. Park, H. Shibuya, I. Adachi, I. Bedny, I. Bizjak, J. B. Singh, J. Brodzicka, J. Dalseno, J. H. Kang, J. Haba, J. Lee, J. Li, J. Ying, J. Zhang, K. Abe, K. Abe, K. Arinstein, K. Belous, K. Hayasaka, K. Ikado, K. Inami, K. Kinoshita, K. Miyabayashi, K. Senyo, K. Sumisawa, K. Tamai, K. Trabelsi, K. Ueno, L. E. Piilonen, L. M. Zhang, M. Barbero, M. Bračko, M. Danilov, M. Dash, M. E. Sevior, M. Hazumi, M. Iwasaki, M. Nakao, M. Shapkin, M. Starič, M. Tanaka, M. Yamauchi, M.-C. Chang, N. C. Hastings, N. Gabyshev, N. Katayama, N. Sato, N. Satoyama, N. Soni, N. Tamura, O. Nitoh, O. Schneider, P. Chang, P. Kapusta, P. Križan, P. Krokovny, P. Urquijo, Q. L. Xie, R. Chistov, R. Itoh, R. Kulasiri, R. Kumar, R. Mizuk, R. Pestotnik, R. Seidl, R. Stamen, S. Bahinipati, S. Blyth, S. Cole, S. Eidelman, S. Hou, S. K. Kim, S. Korpar, S. L. Olsen, S. M. Kim, S. Nishida, S. Ogawa, S. Okuno, S. Stanič, S. Suzuki, S. Uehara, S. Uno, S. Villa, S.-K. Choi, S.-W. Lin, T. Aushev, T. E. Browder, T. Gershon, T. Hara, T. Iijima, T. Kawasaki, T. Lesiak, T. Matsumoto, T. Mori, T. Nozaki, T. Ohshima, T. Okabe, T. Schietinger, T. Sumiyoshi, T. Tsuboyama, T. Tsukamoto, T. Uglov, U. Bitenc, V. Balagura, V. Zhilich, W. Mitaroff, W. Ostrowicz, W. T. Chen, W.-S. Hou, X. C. Tian, Y. Asano, Y. B. Hsiung, Y. Chao, Y. Choi, Y. Hoshi, Y. Iwasaki, Y. K. Choi, Y. Mikami, Y. Miyazaki, Y. Sakai, Y. Teramoto, Y. Unno, Y. Usov, Y. Watanabe, Y. Yuan, Y.-J. Kwon, Z. Natkaniec, Z. P. Zhang +173 morecore +1 more source
