Results 71 to 80 of about 9,151,209 (331)

Confidence regions for the multinomial parameter with small sample size [PDF]

, 2008
Consider the observation of n iid realizations of an experiment with d>1 possible outcomes, which corresponds to a single observation of a multinomial distribution M(n,p) where p is an unknown discrete distribution on {1,...,d}. In many applications, the
Blyth C. R., Brown L. D., Didier Concordet, Djalil Chafaï   +3 more
core   +6 more sources

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego, Kellee Parker, William C. Thomsen, James B. Ford, Mallorie B. Heneghan, David Spencer Mangum, Jennifer L. McNeer, Luke D. Maese, Claire E. F. Miller, Richard Lemons, Taumoha Ghosh   +10 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Confidence Region for a Linear Relation

The Annals of Mathematical Statistics, 1964
The analysis of a linear relation is considered, when there are replications and all the variables involved are subject to errors or fluctuations. A test based on the $F$ distribution is derived for testing the hypothesis that the unknown relation is a given linear relation.
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Search for the decay K+ to pi+ gamma gamma in the pi+ momentum region P>213 MeV/c

, 2005
We have searched for the K+ to pi+ gamma gamma decay in the kinematic region with pi+ momentum close to the end point. No events were observed, and the 90% confidence-level upper limit on the partial branching ratio was obtained, B(K+ to pi+ gamma gamma,
A. Konaka, A. Kushnirenko, A.N. Khotjantsev, A.P. Kozhevnikov, A.V. Artamonov, Adler, Adler, Adler, Adler, Alavi-Harati, Anisimovsky, Atiya, Atiya, B. Bassalleck, B. Bhuyan, B. Lewis, B. Viren, Bassalleck, Blackmore, Bryman, Buchalla, Buras, Cappiello, Cappiello, Chiang, Cohen, D'Ambrosio, D'Ambrosio, D'Ambrosio, D.A. Bryman, D.E. Jaffe, D.I. Patalakha, D.V. Vavilov, Donoghue, Doornbos, E.J. Ramberg, E.W. Blackmore, Ecker, Ecker, Ecker, Eidelman, Feldman, G. Redlinger, Gabbiani, Gabbiani, I.-A. Christidi, I.-H. Chiang, J. Hu, J. Mildenberger, J.A. Macdonald, J.S. Frank, K. Mizouchi, K. Omata, K.K. Li, Kitching, Komatsubara, L.G. Landsberg, L.S. Littenberg, Lai, M. Kobayashi, M. Miyajima, M. Nomachi, M.M. Khabibullin, M.V. Diwan, Melić, Mineev, N. Muramatsu, N.V. Yershov, O.V. Mineev, P. Kitching, P.S. Cooper, R. Poutissou, R. Tschirhart, R.C. Strand, S. Chen, S. Kabe, S. Sugimoto, S.H. Kettell, S.V. Petrenko, T. Fujiwara, T. Nakano, T. Nomura, T. Numao, T. Sato, T. Sekiguchi, T. Shinkawa, T. Tsunemi, T. Yoshioka, T.K. Komatsubara, Trampetić, V.A. Mukhin, V.F. Obraztsov, Y. Tamagawa, Y. Yoshimura, Yoshioka, Yu.G. Kudenko   +95 more
core   +1 more source