Results 71 to 80 of about 256,836 (264)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The methods and algorithms for generating of program trajectories for robotic manipulators of arc welding

Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The new effective methods and algorithms were developed for generating of program trajectories for robotic manipulators of arc welding with account of technological limits.
M. M. Kozhevnikov, O. A. Chumakov, I. E. Ilushin, L. A. Loboreva   +3 more
doaj  

Biomechanical Modeling of Finger Joints Based on Dimeric Kinematics

Current Directions in Biomedical Engineering
In the literature, the proximal and distal interphalangeal joints (PIP and DIP) are usually described as singleaxis hinge joints, whereas the metacarpophalangeal (MCP) joint is typically described as a two-axis joint.
Franke Marc, Bogdan Martin
doaj   +1 more source

The Relationship Between Spatial Configuration and Social Interaction in High-Rise Flats: A Case Study On The Jatinegara Barat in Jakarta.

SHS Web of Conferences, 2018
The construction of high-rise flats to minimize urban slum areas in Indonesia still create space use behavior problems for its residents due to the changes of space configuration between high-rise landed housing.
Ridwana Rifan, Prayitno Budi, Utomo Hatmoko Adi   +2 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Robotic Arm C‐Space Trajectory Planning Using Large‐Scale Digital Twin Parallelism and Safety‐Prioritisable Optimal Search Algorithm

IET Cyber-systems and Robotics
This paper proposes a trajectory planning approach based on the configuration space (C‐space) generated from large‐scale digital twinning. Leveraging GPU‐based parallelism, the C‐space of a multi‐degree‐of‐freedom (multi‐DoF) manipulator in a complex ...
Tengyue Wang, Zhefan Lin, Yunze Shi, Songjie Xiao, Liangjing Yang   +4 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Noncommutativity in Configuration Space Induced by a Conjugate Magnetic Field in Phase Space

Mathematics
An external magnetic field in configuration space coupled to quantum dynamics induces noncommutativity in its velocity momentum space. By phase space duality, an external vector potential in the conjugate momentum sector of the system induces ...
Jan Govaerts
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Pointwise Reconstruction of Wave Functions from Their Moments through Weighted Polynomial Expansions: An Alternative Global-Local Quantization Procedure

Mathematics, 2015
Many quantum systems admit an explicit analytic Fourier space expansion, besides the usual analytic Schrödinger configuration space representation. We argue that the use of weighted orthonormal polynomial expansions for the physical states (generated ...
Carlos R. Handy, Daniel Vrinceanu, Carl B. Marth, Harold A. Brooks   +3 more
doaj   +1 more source