Results 81 to 90 of about 256,836 (264)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
KAM theory in configuration space
Commentarii Mathematici Helvetici, 1989 A Hamiltonian system is considered in the 2n-dimensional space and the Hamiltonian is supposed to be periodic in the first n coordinates, i.e. the system is defined on \(T^ n\times R^ n\) where \(T^ n\) is the n- dimensional torus. The problem is transformed into a variational problem whose Euler-Lagrange equation gives rise to a nonlinear partial ...
Zehnder, Eduard, Salamon, Dietmar
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Deep Learning Accelerators' Configuration Space Exploration Effect on Performance and Resource Utilization: A Gemmini Case Study. [PDF]
Sensors (Basel), 2023 Gookyi DAN +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Formal Classification & Spatial Configuration in Vernacular Housing: A Comparative Study on the Zoning of the Reception Area in Traditional Houses of Kerman Province [PDF]
مسکن و محیط روستا, 2012 3 Space syntax is an approach for reading the socio-spatial configuration in architecture and urban areas in order to understand the social logic of space.
Hesam Kamlipour +3 more
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Automated exploitation of the big configuration space of large adsorbates on transition metals reveals chemistry feasibility. [PDF]
Nat Commun, 2022 Gu GH, Lee M, Jung Y, Vlachos DG.
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source