Results 91 to 100 of about 472,552 (281)

Correlation between accessibility to urban open spaces and city livability: case of Abu Dhabi, UAE, and Biskra city, Algeria

Frontiers in Sustainable Cities
Open spaces, such as parks, plazas, and urban voids, play a crucial role in enhancing human well-being and significantly contribute to the overall quality of urban life.
Rim Meziani, Heba Al Sayyed, Hafnaoui Hamzaoui, Safia Mahfoud, Hadjira Sakhri, Dua'a Al-Rifai, Yassine Bada   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

HOS: A Hybrid Metaheuristic One-Parameter-at-a-Time Strategy for T-Way Test Case Generation

IEEE Access
Interactions between software configuration parameters are a main source of system failures. However, the exponential growth of configuration spaces makes exhaustive testing impossible.
Muhammad Sabo Yahaya, Ahmad Sobri Hashim, Sani Tijjani, Jabir Abubakar Salisu, Fatima Sabo Usman, Garba Elhuseini   +5 more
doaj   +1 more source

Monodromy relations from twisted homology

Journal of High Energy Physics, 2019
We reformulate the monodromy relations of open-string scattering amplitudes as boundary terms of twisted homologies on the configuration spaces of Riemann surfaces of arbitrary genus.
Eduardo Casali, Sebastian Mizera, Piotr Tourkine   +2 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

KAM theory in configuration space

Commentarii Mathematici Helvetici, 1989
A Hamiltonian system is considered in the 2n-dimensional space and the Hamiltonian is supposed to be periodic in the first n coordinates, i.e. the system is defined on \(T^ n\times R^ n\) where \(T^ n\) is the n- dimensional torus. The problem is transformed into a variational problem whose Euler-Lagrange equation gives rise to a nonlinear partial ...
Zehnder, Eduard, Salamon, Dietmar
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Assessing the Distribution of Urban Green Spaces and its Anisotropic Cooling Distance on Urban Heat Island Pattern in Baotou, China

ISPRS International Journal of Geo-Information, 2016
An essential part of urban natural systems, urban green spaces play a crucial role in mitigating the urban heat island effect (UHI). The UHI effect refers to the phenomenon where the temperature within a city is higher than that of the surrounding rural ...
Tongliga Bao, Xueming Li, Jing Zhang, Yingjia Zhang, Shenzhen Tian   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source