Results 111 to 120 of about 474,935 (329)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

The use of landscape units as a methodology tool for the open space system analysis

Pós: Revista do Programa de Pós-Graduação em Arquitetura e Urbanismo da FAUUSP, 2016
This paper presents a study on the urban form, landscape and open spaces of Patos de Minas, an average city of Minas Gerais, Brazil. Searching to understand the configuration of the Open Spaces System by applying the methodology of Landscape Units.
Nayara Cristina Rosa Amorim, Glauco de Paula Cocozza   +1 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Asymptotic growth of Betti numbers of ordered configuration spaces on an elliptic curve

, 2020
Roberto Pagaria
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Exploring the Impact of Public Spaces on Social Cohesion in Resettlement Communities from the Perspective of Experiential Value: A Case Study of Fuzhou, China

Buildings
With the rapid pace of global urbanization, the urbanization of resettlement communities in China has garnered increasing attention from scholars. This study, grounded in experiential value theory, delves into the relationship between public spaces in ...
Yafeng Lai, Pohsun Wang, Kuohsun Wen
doaj   +1 more source

Exploring the configuration spaces of surface materials using time-dependent diffraction patterns and unsupervised learning. [PDF]

Sci Rep, 2020
Packwood DM.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Research on the aging-suitability of community outdoor spaces in Zhengzhou based on the analytic hierarchy process and semantic differential method

Frontiers in Public Health
BackgroundAs global populations age, the suitability of community outdoor spaces for older adult residents has become a critical urban planning concern. However, comprehensive evaluation methods for assessing these spaces are lacking.
Chang Gao, Shengnan Wang, Pengpeng Li, Wenbo Jia, Kai Feng   +4 more
doaj   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source