Results 151 to 160 of about 4,596,099 (356)

Experimental and numerical studies on rock damage law in straight-hole cut blasting under biaxial confining pressure

International Journal of Mining Science and Technology
To study the relationships between rock mass crack propagation and damage and confining pressure under blast impact loading during straight-hole cut blasting, tests were performed under different confining pressures.
Xiantang Zhang, Zhaobin Li, Hui Yu, Hongmin Zhou, Hongli Wang, Xiangtuan Jiao, Fuzhi Wang   +6 more
doaj   +1 more source

Transport of micron-sized polyethylene particles in confined aquifer: Effects of size, aging, and confining pressure. [PDF]

Heliyon, 2023
Chen X, Wan Y, Jia J, Qiang X, Wu C.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Experimental investigation on mechanical properties and permeability evolution law of frozen calcareous clay under fluid-solid coupling

Case Studies in Construction Materials
In the Huainan-Huaibei deep tundra mining project, groundwater seepage and complex geostress significantly challenge construction safety. To systematically investigate the mechanical properties and permeability evolution of frozen ground under coupled in-
Lei Chang, Yi Cao, Chuanxin Rong, Shouzhong Feng, Deyuan Kan, Jiyuan Deng, Lezhang Xing   +6 more
doaj   +1 more source

Chemical Corrosion-Water-Confining Pressure Coupling Damage Constitutive Model of Rock Based on the SMP Strength Criterion. [PDF]

Materials (Basel), 2023
Chen Y, Tong H, Chen Q, Du X, Wang S, Pan Y, Dong Y, Ma H.   +7 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Influence of Confining Pressure on Nonlinear Failure Characteristics of Coal Subjected to Triaxial Compression. [PDF]

Int J Environ Res Public Health, 2022
Li Q, Liu J, Lu S, Wang Z, Wang H, Wu Y, Wang Y, Ying D, Li M.   +8 more
europepmc   +1 more source

Characterization of Asphalt Treated Base Course Material [PDF]

, 2010
INE/AUTC 11 ...
Li, Peng, Liu, Juanyu
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Experiment Study on the Influence of Density and Confining Pressure on Triaxial Shear Properties of Calcareous Sand. [PDF]

Materials (Basel), 2023
Zhang H, Ren H, Mu C, Wu X, Huang K, Wang F.   +5 more
europepmc   +1 more source