Results 171 to 180 of about 23,904 (309)

Analysis of fracture deformation field and energy evolution of granite after high confining pressure cyclic load pre-damage. [PDF]

R Soc Open Sci, 2021
Yang D, Hu J, Wen G, Zeng P.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Mechanical response of high-porosity rocks under high triaxial confining pressure and experimental study of indentation tests. [PDF]

PLoS One
Gai J, Li W.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Seepage forces and confining pressure effects on piping erosion

, 1998
An experimental study of piping erosion is presented. Various artificial granular filter and soil combinations are tested in a permeameter under variable confining pressures to determine the critical gradient where soil erodes through the filter ...
Tomlinson, Scott Stewart
core  

Influence of confining pressure and stress amplitude on the mechanical properties and permeability characteristics of coal. [PDF]

Sci Rep
Yang H, Qin D, Liu H, Sun X, Ran Q, Hu Y.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effects of confining pressure and loading direction on the mechanical behavior of schist with high content and aggregation degree of mica. [PDF]

PLoS One
Liu Q, Xiang J, Yin X, Song K.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Experimental Study on Damage Constitutive Model of Rock under Thermo-Confining Pressure Coupling

Underground engineering frequently encounters the challenges of high temperatures and high confining pressures. The combined effects of temperature and confining pressure can significantly alter the mechanical properties of rock. Evaluating the impact of
Yonglai Zheng, Tanbo Pan, Yifan Ji, Xin Lan, Chenyu Hou, Zhengxie Zhang   +5 more
core   +1 more source