Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Study on a Creep Constitutive Model of Phyllite Considering the Coupling Factors of Bedding, Confining Pressure, and Water Saturation. [PDF]
Wu Y, Hu J, Yang D, Wen G.
europepmc +1 more source
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Synergistic effects of crystal habit and confining pressure on the compressive mechanical behavior of crystalline rock: a grain-based modeling analysis. [PDF]
Zhan Z +5 more
europepmc +1 more source
Innovative Apparatus for Testing Filtration, Sorption and CO2/CH4 Exchange Sorption Processes Under Isobaric Conditions on Sorbent Subjected to Confining Pressure in Terms of Laboratory Tests of CO2-ECBM Technology. [PDF]
Kudasik M, Skoczylas N, Pajdak A.
europepmc +1 more source
Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein +13 more
wiley +1 more source
Growth of nonmotile stress-responsive bacteria in 3D colonies under confining pressure. [PDF]
Rahbar S +3 more
europepmc +1 more source
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman +9 more
wiley +1 more source
Study on the Cyclic Impact Mechanical Characteristics of Coal under Confining Pressure. [PDF]
Yongliang H, Liying S, Xuegang X.
europepmc +1 more source
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji +13 more
wiley +1 more source

