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Data-Driven and Confirmatory Subgroup Analysis in Clinical Trials

2020
In this chapter we provide an overview of the principles and practice of subgroup analysis in late-stage clinical trials. For convenience, we classify different subgroup analyses into two broad categories: data-driven and confirmatory. The two settings are different from each other primarily by the scope and extent of pre-specification of patient ...
Alex Dmitrienko   +3 more
openaire   +1 more source

Pairwise stochastic approximation for confirmatory factor analysis of categorical data

British Journal of Mathematical and Statistical Psychology
Abstract Pairwise likelihood is a limited‐information method widely used to estimate latent variable models, including factor analysis of categorical data. It can often avoid evaluating high‐dimensional integrals and, thus, is computationally more efficient than relying on the full likelihood.
Alfonzetti G.   +3 more
openaire   +5 more sources

Psychometric Characteristics of the Minimum Data Set I: Confirmatory Factor Analysis

Journal of the American Geriatrics Society, 1998
OBJECTIVE: To determine the structure and statistical reliability of the federally mandated Minimum Data Set (MDS). DESIGN: Confirmatory, hypothesis‐testing factor analysis was performed on MDS protocols of 733 nursing home residents.
R, Casten   +3 more
openaire   +2 more sources

Main Study—Data Reduction and Confirmatory Factor Analysis

2017
The main research study consists of obtaining feedback through the questionnaire developed from all the organizations identified for data collection. In this context, a sample size of 270 organizations was considered for the main study. Out of 270 samples, 150 are from Bangalore region (Karnataka) and remaining 120 from Coimbatore region (Tamil Nadu ...
R. Srinivasan, C. P. Lohith
openaire   +1 more source

Quantified Neurophysiology with mapping: Statistical inference, Exploratory and Confirmatory data analysis

Brain Topography, 1990
Topographic mapping of brain electrical activity has become a commonly used method in the clinical as well as research laboratory. To enhance analytic power and accuracy, mapping applications often involve statistical paradigms for the detection of abnormality or difference.
F H, Duffy   +5 more
openaire   +2 more sources

FROM EXPLORATORY TO CONFIRMATORY: TOWARDS DATA VISUALIZATION AS A COMPLETE ANALYSIS TOOL

2023
Confirmatory statistics tests, performed and written with equations, are a standard in scientific publications, but may represent a barrier to entry for novice analysts who have less familiarity with purely calculative methods. Data visualization, often touted as useful for sharing completed analyses with lay audiences, is often used for early-stage ...
openaire   +2 more sources

Incorporating external real-world data (RWD) in confirmatory adaptive design

Journal of Biopharmaceutical Statistics
Adaptive designs, such as group sequential designs (and the ones with additional adaptive features) or adaptive platform trials, have been quintessential efficient design strategies in trials of unmet medical needs, especially for generating evidence from global regions.
Junjing Lin, Jianchang Lin
openaire   +2 more sources

Confirmatory data on habenular projections

Brain Research, 1979
E G, McGeer   +2 more
openaire   +2 more sources

Prevalence of Agoraphobia: Some Confirmatory Data

Psychological Reports, 1987
C A, Pollard, J G, Henderson
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