Results 81 to 90 of about 95,919 (260)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Social Skills Rating System - Brazilian Version: New Exploratory and Confirmatory Factorial Analyses

Avances en Psicología Latinoamericana, 2014
This study aimed to verify the Factorial Structure of the Brazilian version of the Social Skills Rating System (SSRS-BR), with an extended sample of participants, and their subsequent Confirmatory Factor Analyses in another subset of data.
Lucas Cordeiro Freitas, Zilda Aparecida Pereira Del Prette   +1 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Validation and invariance across gender of the Beliefs About Appearance Scale (BAAS) in a community sample of heterosexual adults in a committed relationship

Trends in Psychiatry and Psychotherapy, 2018
Objective To evaluate the psychometric properties of the Beliefs About Appearance Scale (BAAS) in terms of its factorial structure and invariance, reliability, and validity when applied to adults from the community. Methods Participants consisted of 810
Patrícia M. Pascoal, Maria-João Alvarez, Magda Sofia Roberto   +2 more
doaj   +1 more source

Exploratory and confirmatory factor analyses identify three structural dimensions for measuring physical function in community-dwelling older adults. [PDF]

PeerJ, 2023
Jiang G, Tan X, Wang H, Xu M, Wu X.
europepmc   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Validation of the Japanese Version of the Multidimensional Measure of Family Supportive Supervisor Behaviors (FSSB-J)

Frontiers in Psychology, 2019
ObjectiveThe aim of the current study was to validate the Japanese version of the family supportive supervisor behaviors (FSSB-J) measure. FSSB is conceptualized as a multidimensional, superordinate construct constituted of four dimensions: emotional ...
Hisashi Eguchi, Yuko Kachi, Hayami K. Koga, Mariko Sakka, Masahito Tokita, Akihito Shimazu, Akihito Shimazu   +6 more
doaj   +1 more source

Rasch and Confirmatory Factor Analyses of the Arabic Version of the Diabetes Self-Management Scale (DSMS): An Intercultural Approach. [PDF]

Healthcare (Basel), 2022
Kaabi YA, Alshaikh NA, Jerah AA, Halawi MA, Habibullah MM, Abdelwahab SI.   +5 more
europepmc   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source