Results 181 to 190 of about 4,195,887 (419)

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Confirmatory factor analysis way to achieve validity [PDF]

open access: yesمجله ایرانی آموزش در علوم پزشکی, 2015
Saeid Talebi
doaj  

Development of a Chinese Human-Automation Trust Scale [PDF]

open access: yesarXiv
The development of a reliable and valid assessment tool of human-automation trust is an important topic. This study aimed to develop a Chinese version of human-automation trust scale (C-HATS) with reasonable reliability and validity based on Lee and See (2004)'s trust model.
arxiv  

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

open access: yesMolecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar   +4 more
wiley   +1 more source

Understanding the relationships between the perceptions of burnout and instability in Software Engineering [PDF]

open access: yesarXiv
Changes are inherent in software development, often increasing developers' perception of instability. Understanding the relationship between human factors and Software Engineering processes is crucial to mitigating and preventing issues. One such factor is burnout, a recognized disease that impacts productivity, turnover, and, most importantly ...
arxiv  

A Single Factor Underlies the Metabolic Syndrome: A confirmatory factor analysis [PDF]

open access: bronze, 2006
Manel Pladevall   +11 more
openalex   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

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