Results 181 to 190 of about 417,168 (325)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Estimating the minimal important change of single-item measures using the adjusted predictive modeling method or the longitudinal confirmatory factor analysis method. [PDF]

Qual Life Res
Terluin B, Pua YH, Fromy P, Trigg A, van der Zwaard B, Bjorner JB.   +5 more
europepmc   +1 more source

Modeling Measurement as a Sequential Process: Autoregressive Confirmatory Factor Analysis (AR-CFA) [PDF]

, 2019
Ozlem Ozkok, Michael J. Zyphur, Adam Barsky, Max Theilacker, M. Brent Donnellan, Frederick L. Oswald   +5 more
openalex   +1 more source

Sporting, financial and stock market performance in English football: an empirical analysis of structural relationships [PDF]

This paper uses structural equation modeling to examine the linkages between financial performance, sporting performance and stock market performance for English football clubs over the period from 1995 to 2007.
Antonio Samagaio, Eduardo Couto, Jorge Caiado   +2 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Confirmatory factor analysis of competing PANSS negative symptom models: data from OPTiMiSE first-episode schizophrenia study. [PDF]

BJPsych Open
Demjaha A, Stahl D, Arango C, Glenthøj B, Rodriguez-Jimenez R, Díaz-Caneja CM, Baandrup L, Ebdrup B, Paz Garcia-Portlla M, Diaz-Marsa M, Winter-van Rossum I, Kahn R, Dazzan P, McGuire P.   +13 more
europepmc   +1 more source

Confirmatory factor analysis of self-evaluation spatial thinking skills (SESS) measurement model [PDF]

, 2020
Mushi Saumu Athumani, Mohamad Sahari Nordin, Azlina Mustaffa   +2 more
openalex   +1 more source

The Good Governance Indicators of the Millennium Challenge Account: How many dimensions are really being measured [PDF]

This paper assesses the validity of the perception-based governance indicators used by the US Millennium Challenge Account (MCA) for aid allocation decisions.
Knoll, Martin, Zloczysti, Petra
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Validating the Emotional Well-Being Questionnaire in Type 2 Diabetes: A Pilot Confirmatory Factor Analysis. [PDF]

Patient Relat Outcome Meas
Randväli M, Šteinmiller J, Sundberg K, Toomsoo T.   +3 more
europepmc   +1 more source