Results 171 to 180 of about 461,964 (264)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Policy frameworks for promoting public hospital development in major economies: implications for China. [PDF]

Front Public Health
Shu Y, Li Z, Xie R.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Work-family conflict, depression, burnout, and perceived patient safety culture among ICU nurses in four tertiary hospitals in the Western Region of Saudi Arabia: a cross-sectional study. [PDF]

BMC Nurs
Rawas H, de Beer J, Alhazmi A, Beheri W, Ashrour S, Abu Shhadeh A, Saifan AR, Al-Yateem N.   +7 more
europepmc   +1 more source

The Development of gate-keeping functions in Central and Eastern Europe and the CIS: Lessons from Bulgaria, Kazakhstan and Ukraine. [PDF]

, 2010
Bilson, Andy
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Sudanese physicians' insights on managing stroke during Sudan's war 2024. [PDF]

BMC Neurol
Mohammed FEA, Ahmed MJ, MohamedAhmed BBA, Mohamed A, Elfatih Ahmed NM, Gandour HMN, Mohamed Idris EE, Mohammed Salih SMSM, Saeed ASA, Elseed AAA, Mohamed Idris MO, Mohammed TZE, Mustafa AKA, Gaili RA, Saeed SAA, Saad KAH, MohammedAhmed MBA, Suliman SAY, Elawad MSG, Fadlelmoula YAD, Mustafa GA, Mohammed Ahmed KAH.   +21 more
europepmc   +1 more source

The Politics of Trauma System Development [PDF]

, 1995
Hackey, Robert B.
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Survival of hypoxaemic patients treated with solar-powered oxygen in rural Somalia hospitals: a prospective, observational study. [PDF]

EBioMedicine
Ali MM, Njiru HN, Al Azad A, Hossain MS, Asir AA, Anwar I, Ali GA, Adam Abubakar AH, Malik SMMR, Osman AY.   +9 more
europepmc   +1 more source