Results 71 to 80 of about 1,074,730 (257)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Efficient Conflict Detection for Conflict Resolution

, 2018
Accurate tools to detect and solve conflicts are becoming necessary to assist air traffic controllers in their task. Air traffic controllers will eventually rely on tools to test and choose alternative trajectories. Enabling such tools demands a near real-time conflict detection algorithm.
Alligier, Richard, Durand, Nicolas, Alligier, Gregory   +2 more
openaire   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Conflict Detection of Functional Requirements Based on Clustering and Rule-Based System

IEEE Access
Functional requirement identification is the initial stage in software development and a crucial step in the success of software development. Good functional requirements sentences should be consistent with each other or conflict-free.
Sarwosri, Umi Laili Yuhana, Siti Rochimah   +2 more
doaj   +1 more source

Enhancing Conflict Resolution Mechanism for Automatic Model Composition

Applied Computer Systems, 2016
Despite the fact that model composition paradigm becomes very important and most commonly used, the support for their cooperation has not reached its full strength, especially in managing composition conflicts, because it’s often divided between and ...
Marzouki Nisrine El, Ņikiforova Oksana, Lakhrissi Younes, Mohajir Mohammed El   +3 more
doaj   +1 more source

Legal Conflict Detection in Interacting Legal Systems [PDF]

, 2013
Acting under several jurisdictions at the same time is becoming the norm rather than the exception, certainly for companies but also (sometimes without knowing) for individuals. In these circumstances disparities among the different laws are inevitable. Here, we present a mathematical and a computational model of interacting legal specifications, along
Li, T, Balke, T, De Vos, M, Padget, J, Satoh, K   +4 more
openaire   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Randomized algorithms for probabilistic aircraft conflict detection

Proceedings of the 38th IEEE Conference on Decision and Control (Cat. No.99CH36304), 2003
A mid-range conflict alerting system is proposed, based on a measure of criticality which directly takes into account the uncertainty in the prediction of the aircraft positions. The use of randomized algorithms makes the computation of the criticality measure tractable.
PRANDINI, MARIA, J. Lygeros, A. Nilim, S. Sastry   +3 more
openaire   +2 more sources