Results 51 to 60 of about 708,361 (267)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Manajemen Konflik Berbasis Komunitas: Studi Kasus Community Oriented Policing (COP) di Malioboro Yogyakarta

JSP: Jurnal Ilmu Sosial dan Ilmu Politik, 2015
The purpose of this paper want to see how the concept of Community Oriented Policing (COP) applied to manage conflict in the public sphere with capital intensive , multi-actor and multi-interest.
Muhammad Zuhdan
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A systematic literature review of conflict management in hospitality: Towards a multi-stakeholder resource-based conflict-management framework

The hospitality industry has long recognised the need for effective conflict-management. By adopting a theory-informed systematic review approach to analyse 108 journal articles on hospitality conflicts, this study examines the conceptualisations and ...
Wang, Y, Le, TH, Fu, M, Kwek, A
core   +1 more source

The Association of Southeast Asian Nations’ (ASEAN) Conflict Management Approach Revisited: Will the Charter Reinforce ASEAN’s Role?

ASEAS - Austrian Journal of South-East Asian Studies, 2009
The main aim of this study is to assess the role played by the Association of Southeast Asian Nations (ASEAN) in the management and resolution of disputes between its member-states in the South-East Asian region. The ASEAN approach to conflict management
Ramses Amer
doaj  

Pengelolaan Konflik Sumber Daya Alam Terbarukan di Perbatasan dalam Pendekatan Ekologi Politik

Jurnal Hubungan Internasional, 2018
The different interest among actors (government, society, and corporations) has become one of the causes of conflict in natural resources managements. In border areas, conflict arises because of abundant land availability and diverse natural resources ...
Herdis Herdiansyah
doaj   +1 more source

PERANAN KOMUNIKASI INTERPERSONAL DALAM MANAJEMEN KONFLIK PADA PASANGAN SUAMI DAN ISTRI YANG SAMA-SAMA BEKERJA

Jurnal Ranah Komunikasi, 2020
This article examines the conflict management strategies applied by couples and wives who work together in resolving conflicts. The study aims to find out what conflict management strategies are often done by couples and wives who work together in ...
Meri Agustina, Alfan Miko, Asmawi Asmawi
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source