Results 101 to 110 of about 1,248,632 (310)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Youth as a Form of Conflict [PDF]

open access: yes, 2011
This essay is one of six included in the August 3-4, 2011 eSeminar, Revisiting Strategies for Post-Conflict Economic Recovery: Assessing the Findings of the 2011 World Development ReportThe very fact that the World Bank titled the World Bank Development ...
Amara, Jomana
core  

How has the relationship between major financial markets changed during the Russia–Ukraine conflict?

open access: yesHumanities & Social Sciences Communications
Geopolitics events have a significant impact on financial markets in the process of global economic integration and financial liberalization. Focusing on the 2022 Russia-Ukraine conflict, this paper utilizes the TVP-VAR network connectedness approach to ...
Ping Li   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

The labor market, education and armed conflict in Tajikistan [PDF]

open access: yes
Shortly following its independence in 1991, Tajikistan suffered a violent civil war. This study explores the effect of this conflict on education and labor market outcomes for men and women.
Shemyakina, Olga N.
core  

Does Trade Integration Contribute to Peace? [PDF]

open access: yes
This paper investigates the effect of trade integration on military conflict. Our empirical analysis,based on a large panel data set of 290,040 country-pair observations from 1950 to 2000, confirms that an increase in bilateral trade interdependence and ...
Lee, Jong-Wha, Pyun, Ju Hyun
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Mediation in marital conflicts: the persistence of conflict and the clinical point of view

open access: yes, 2021
Este estudo parte de uma realidade complexa, relativa às novas configurações dos vínculos familiares e das possibilidades de conflitos inerentes a essa situação. A investigação lança um olhar, do ponto de vista psicológico, sobre situações de mediação de conflitos nas separações conjugais, nos casos em que a intensidade do conflito tende a perdurar ao ...
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Exploring Message Targeting at Home and Abroad: The Role of Political and Media Considerations in the Rhetorical Dynamics of Conflict Resolution

open access: yesInternational Journal of Communication, 2017
Targeting messages on sensitive, conflict-related issues while mediating between disparate audience expectations presents a significant risk to the image and interests of political actors.
Elie Friedman   +2 more
doaj  

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