Results 121 to 130 of about 1,248,632 (310)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

"Economic Aid to Post-conflict Countries: A Methodological Critique of Collier and Hoeffler" [PDF]

open access: yes
This paper retests the analysis of "Aid Policy and Growth in Post-Conflict Societies," by Paul Collier and Anke Hoeffler (October 2002 and forthcoming in European Economic Review).
Astri Suhrke   +2 more
core  

The Arab Gulf countries and the Arab- Israeli conflict;: the linkages and dynamics (1970-2000) [PDF]

open access: yes, 2004
This thesis examines the changing linkages and dynamics of the relationship between the Arab Gulf countries and the Arab-Israeli conflict through the period of 1970-2000.
El-Hamad, Jawad M. A.
core  

CULTURES AND CONFLICT: OSWALD SPENGLER

open access: yesИстраживања, 2012
In this paper the authors try to present and analyze the views of a German thinker,Oswald Spengler on social conflicts. The first part of the text deals with Spengler’s method,which points out the need of different approach to nature on the one side, and
Срђан Шљукић   +1 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Structural Stability: On the Prerequisites of Nonviolent Conflict Management [PDF]

open access: yes
The concept of “structural stability” has been gaining prominence in development policy circles. In the EU’s and the OECD Development Assistance Committee’s (OECD DAC) understanding, it describes the ability of societies to handle intra-societal conflict
Christian von Soest   +4 more
core  

The Failures of the United Nations Security Council's Resolutions in Addressing the Russia-Ukraine Conflict: Case Study of Resolution No. S/RES/2202 of 2015

open access: yesWIMAYA
This study aims to analyze the failure of Resolution No. S/RES/2202 of 2015, issued by the United Nations Security Council (UNSC), to address the conflict between Russia and Ukraine during 2014-2015.
Zulfikar Suardi   +2 more
doaj   +1 more source

Water as a Source of Conflicts: A Review of the Focal Points for Conflicts in the World

open access: yesRevista CIDOB d'Afers Internacionals, 1999
Since time immemorial, the access to water has been the source of power or become the apple of discord that has originated great conflicts. Today, thanks to the development of understanding in the area of water sciences, one may observe with greater clarity whichcontinents are more at risk to possible conflicts because of their elevated populations and
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Turning Points That Led to Change in Married Couples\u27 Approach to Conflict

open access: yes, 2014
The purpose of the study was to understand whether or not people believe their approach to conflict changes, and if so, what turning points lead to change. Seven of the ten interviewees believed that either they or their spouses had made changes to their
Schmidt, Jana
core  

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