Results 61 to 70 of about 725,674 (302)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Conflict Prevention in Rural Development: Strengthening the Authority of Village Autonomy

Bestuurskunde
Village development is one of the main pillars in the effort to improve community welfare and promote economic equity. Although the number of advanced and self-sufficient villages has continued to increase, the gap between rural and urban areas remains ...
Desi Natalia Sihombing, Djayeng Tirto, Arifuddin Uksan   +2 more
doaj   +1 more source

Preventive Diplomacy and Conflict Prevention: Obstacles and Opportunities

Stability : International Journal of Security and Development, 2012
Preventive diplomacy, conflict prevention and other forms of preventive action intended to stop armed conflicts before they escalate to widespread violence are the subject of intense debate.
Steven A. Zyck, Robert Muggah
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Conflict Prevention through Post Conflict Housing Reconstruction: Good Practices and Lessons Learned

, 2015
The concept of ‘DRR’ within natural and technological disasters context conform to the concept of ‘conflict prevention and peace building’ within conflicts or wars context.
Seneviratne, Krisanthi, Haigh, Richard P., Amaratunga, Dilanthi, Haigh, Richard, Seneviratne, Krisanthi (R20001)   +4 more
core  

Analysis and advocacy on a European policy on conflict prevention: a viewpoint

, 1998
The author identifies three key weaknesses in the debate leading up to establishing the Common Foreign and Security Policy (CFSP) for the European Union (EU).
Van Brabant, Koenraad
core   +1 more source

New Technology and the Prevention of Violence and Conflict

Stability : International Journal of Security and Development, 2013
Amid unprecedented growth in access to information communication technologies (ICTs), particularly in the developing world, how can international actors, governments, and civil society organizations leverage ICTs and the data they generate to more ...
Francesco Mancini, Marie O'Reilly
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Prenegotiation : promises for conflict prevention

This chapter summarizes the literature on prenegotiation - that is, the literature on the iterative process in which (conflict) parties employ measures that can redefine their relationship through the reconfiguration of the parties’ respective and ...
Hegele, Lukas,
core   +1 more source