Results 81 to 90 of about 2,644,756 (299)

Scarcity induces conflict in Puerto Rican fisheries

Environmental Research Letters
Small-scale fisheries provide vital food security for coastal communities worldwide, yet they face numerous challenges. In particular, fisheries conflicts arise when a marine resource is contested or disputed between a minimum of two actors.
Nicolás X Gómez-Andújar, A John Woodill, Ciera Villegas, James R Watson   +3 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Functional Coexistence in Socio-Political Conflict

This book introduces the concept of functional coexistence as a context for building practical strategies for long-term conflict intervention and social change.

core   +1 more source

Evaluating U-left turn and direct left turn movements at signalized intersections using traffic conflict indices

Journal of Traffic and Transportation Engineering (English ed. Online)
This research aims to analyze and compare the impact of U-left turn (ULT) and direct left turn (DLT) movements on safety and traffic flow using traffic conflict indices as a non-crash data methodology.
Abbas Sheykhfard, Farshidreza Haghighi, Akram Aziz Zadeh, Subasish Das, Mohammad Mehdi Oshanreh, Khaled Shaaban, Ali Soltani   +6 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Financial Leasing as a Policy Instrument for Emergency Green-Energy Security Under Geopolitical Conflict: A Tripartite Evolutionary Game Analysis

Energies
Under geopolitical conflicts, the deployment of emergency green energy in energy-import-dependent countries is constrained by limited upfront capital and uncertainty regarding the conflict duration.
Haibo Chen, Yan Liang, Zongjun Wang, Jinrong Huang   +3 more
doaj   +1 more source

Traffic conflict assessment for non-lane-based movements of motorcycles under congested conditions

IATSS Research, 2014
Traffic conflict under congested conditions is one of the main safety issues of motorcycle traffic in developing countries. Unlike cars, motorcycles often display non-lane-based movements such as swerving or oblique following of a lead vehicle when ...
Long Xuan Nguyen, Shinya Hanaoka, Tomoya Kawasaki   +2 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source