Results 91 to 100 of about 1,787,762 (305)
Behavioral SciencesTransforming the course of protracted and bloody conflicts requires changing the behaviors and minds of society members who take part in these conflicts.
Nimrod Rosler +3 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Journal of Contemporary Rituals and TraditionsPurpose of the Study: This study investigates the diverse roles of the Ọkọnkọ Society in Umuahia, Nigeria, particularly its use of Igbo language and cultural practices in conflict resolution and cultural preservation, challenging the conventional view of
Ugo Aniga
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
, 2018 Parent–adolescent conflict is normative, and whether and how conflicts are resolved tend to be more important for adolescent adjustment than the actual occurrence of conflicts. On average, both parents' and adolescents' use of positive conflict resolution tends to increase, and negative conflict resolution tends to decrease, with age, although ...
openaire +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Contemporary conflict resolution
, 2005 Since the end of the Cold War, conflict prevention and resolution, peacekeeping and peacebuilding have risen to the top of the international agenda. The third edition of this hugely popular text explains the key concepts, charts the development of the field, evaluates successes and failures, and assesses the main current challenges and debates in the ...
Woodhouse, Thomas +2 more
openaire +2 more sources
Stability maintenance at the grassroots: China’s weiwen apparatus as a form of conflict resolution [PDF]
, 2013 This working paper explores the history and potential of “stability maintenance” (weiwen) as a form of conflict resolution in China. Its emphasis on conflict resolution is novel.
Benney, Jonathan
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source