Results 81 to 90 of about 1,787,762 (305)

NATIONAL SECURITY: A RE-ENGAGEMENT WITH CONCEPTS, STRUCTURES, AND PLANS

open access: yesInternational Studies Journal, 2022
The paper  has demonstrated how Nigeria national security strategy was militarily in the past and how the amended  Nigeria national security strategy under the President Buhari’s administration brought human security to it which is  in line with global ...
Ochoga Edwin Ochoga, Binta Sidi
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Have Coping Resources and Trust in State Institutions Helped Jews and Arabs to Overcome Stress During the Iron Swords War?

open access: yesEuropean Journal of Investigation in Health, Psychology and Education
The events of 7 October 2023 and the subsequent Iron Swords War have profoundly impacted Israeli society, leaving both Jewish and Arab populations exposed to unprecedented levels of violence and uncertainty.
Orna Braun-Lewensohn   +2 more
doaj   +1 more source

CHALLENGES OF LOCALIZATION OF THE POLICY FRAMEWORK AND NATIONAL ACTION PLAN FOR PREVENTING VIOLENT EXTREMISM IN PLATEAU STATE, NIGERIA

open access: yesInternational Studies Journal, 2023
The study examines the challenges of localization of the policy framework and national action plan for preventing violent extremism in Plateau state. The paper noted that violent extremism is fundamentally, repudiations of democratic values of tolerance,
BEJI GOWAL BEKUMA, JOHN UKAWUILULU
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

THE IMPLICATIONS OF THE POLITICISATION OF INTERNAL SECURITY IN NIGERIA

open access: yesAyika, 2022
Nigeria, a microcosm of the African continent is a very complex country. With over 250 ethnic nationalities and several religious sects who strive to always work in outdoing each other in the polity, the country is a breeding ground for security breaches.
James Chukwuemeka Mbah   +1 more
doaj  

An Equity Autopsy: Exploring the Role of Water Rights in Water Allocations and Impacts for the Central Valley Project during the 2012–2016 California Drought

open access: yesResources, 2018
Entrenched Western water rights regimes may appear to function relatively well in wet years, but extreme drought events can expose the kinds of harsh ecological and socio-economic outcomes that the hard edges of prior appropriation inherently generate ...
Zachary P. Sugg
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Conflict Resolution: Cultural Understanding Imperative [PDF]

open access: yes, 2012
Business transactions and other potential incidences of conflict resolution must be met by participants who have transcended the isolating and often arrogant traits of individualism and must expand to embrace the collective — to realize the importance of
Tindal, Livingston S
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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