Results 61 to 70 of about 545,156 (279)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Influence of hydraulic resistance on flow features in an open channel confluence [PDF]
, 2014 A numerical model based on the 3D shallow water equations is set up for a 90° angle open channel confluence. The model is first calibrated and validated using experimental data by (Shumate, 1998).
Creëlle, Stéphan +3 more
core
Isotopic characteristics of the Garonne River and its tributaries [PDF]
, 2009 The Garonne is the largest river in the south-west of France, and its drainage basin stretches between the Pyrenees and the Massif Central mountains. Until now, no water stable isotope study has been performed on the whole Garonne river basin which is ...
Amiotte-Suchet +35 more
core +4 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
La convergence des destins chez Thomas Hardy
Cahiers Victoriens et Edouardiens, 2019 In the diegesis of Hardy’s novels, when movements converge to a centre, it means that we are approaching ‘the central place’, ‘the intimate exteriority or “extimacy”’ which Lacan calls the Thing (Lacan 2008, 171). It means that the subject (i.e.
Annie Ramel
doaj +1 more source
The influence of flow discharge variations on the morphodynamics of a diffluence-confluence unit on a large river: Impacts of discharge variation on a diffluence-confluence unit [PDF]
, 2017 © 2017 The Authors. Earth Surface Processes and Landforms published by John Wiley & Sons Ltd. Bifurcations are key geomorphological nodes in anabranching and braided fluvial channels, controlling local bed morphology, the routing of sediment and water,
Aalto, Rolf +6 more
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The language of Stratified Sets is confluent and strongly normalising [PDF]
, 2018 We study the properties of the language of Stratified Sets (first-order logic with $\in$ and a stratification condition) as used in TST, TZT, and (with stratifiability instead of stratification) in Quine's NF.
Gabbay, Murdoch J.
core +2 more sources