Results 61 to 70 of about 298,285 (278)
“One Person, Two Names”: Confluence in Jackie Kay’s Writing
Études Écossaises, 2017 This article examines the many ways in which Jackie Kay’s writing is about confluence: as a Scottish writer with a Nigerian father, as a lesbian poet, as an adopted child, she is situated at the crossroads of our cultural, societal, racial landmarks ...
Marie-Odile Pittin-Hédon
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Modeling Length Adjustment in Alluvial Anabranching Units
Water Resources ResearchAnabranching units form when the stream flow divides into two channels that reconnect downstream. Recent observations indicate that these patterns tend to develop fairly regular planforms, characterized by an average length that scales with reach ...
Niccolò Ragno, Marco Tubino
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Cybergeo, 2017 From a wide variety of maps and iconographic sources, spatially corrected and georeferenced, this work seeks to precisely reconstruct the hydro-morphological changes at the confluence of two main Alpine rivers: Drac and Isère.
Dominique Dumas, Adrien Favillier
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Citizenship: a perverse confluence
, 2007 This article discusses the different meanings that citizenship has assumed in Latin America in the past few decades. Its main argument is that, in the perverse confluence between neo-liberal and democratic participatory projects, the common reference to ...
Dagnino, Evelina, Evelina Dagnino
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source