Results 71 to 80 of about 545,156 (279)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Three models for gene assembly in ciliates: a comparison [PDF]
Computer Science Journal of Moldova, 2010 We survey in this paper the main differences among three variants of an intramolecular model for gene assembly: the general, the simple, and the elementary models.
Miika Langille +2 more
doaj
Cybergeo, 2017 From a wide variety of maps and iconographic sources, spatially corrected and georeferenced, this work seeks to precisely reconstruct the hydro-morphological changes at the confluence of two main Alpine rivers: Drac and Isère.
Dominique Dumas, Adrien Favillier
doaj +1 more source
The impact of significant input of fine sediment on benthic fauna at tributary junctions: a case study of the Bermejo-Paraguay River confluence, Argentina [PDF]
, 2014 This study examines the morphological features, suspended sediment inputs and hydraulic conditions within a large river in association with ecological patterns before and after a tributary confluence.
Amsler, Mario L. +8 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
“One Person, Two Names”: Confluence in Jackie Kay’s Writing
Études Écossaises, 2017 This article examines the many ways in which Jackie Kay’s writing is about confluence: as a Scottish writer with a Nigerian father, as a lesbian poet, as an adopted child, she is situated at the crossroads of our cultural, societal, racial landmarks ...
Marie-Odile Pittin-Hédon
doaj +1 more source
Certification of Confluence Proofs using CeTA [PDF]
, 2015 CeTA was originally developed as a tool for certifying termination proofs which have to be provided as certificates in the CPF-format. Its soundness is proven as part of IsaFoR, the Isabelle Formalization of Rewriting.
Nagele, Julian, Thiemann, René
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Confluence of hypergeometric functions and integrable hydrodynamic type systems
, 2016 It is known that a large class of integrable hydrodynamic type systems can be constructed through the Lauricella function, a generalization of the classical Gauss hypergeometric function. In this paper, we construct novel class of integrable hydrodynamic
Kodama, Y., Konopelchenko, B.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source