Results 81 to 90 of about 584,540 (386)

Selective Inhibition of the MK2 Pathway: Data From a Phase IIa Randomized Clinical Trial in Rheumatoid Arthritis

open access: yesACR Open Rheumatology, 2023
Objective The study objective was to evaluate the safety, tolerability, pharmacodynamics, and preliminary efficacy of ATI‐450 with methotrexate in patients with rheumatoid arthritis (RA).
David Gordon   +7 more
doaj   +1 more source

A Decidable Confluence Test for Cognitive Models in ACT-R

open access: yes, 2017
Computational cognitive modeling investigates human cognition by building detailed computational models for cognitive processes. Adaptive Control of Thought - Rational (ACT-R) is a rule-based cognitive architecture that offers a widely employed framework
D Gall   +6 more
core   +1 more source

Effective field theory as the bridge between lattice QCD and nuclear physics [PDF]

open access: yes, 2006
A confluence of theoretical and technological developments are beginning to make possible contributions to nuclear physics from lattice QCD. Effective field theory plays a critical role in these advances.
Kaplan, David B.
core   +3 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Exploration of quality groundwater through lineament delineation in Okene and its surroudings

open access: yesGeosystems and Geoenvironment
This research addresses the issue of unproductive boreholes in the study area and the limited information on productive aquifers. The challenging geological terrain and dense urbanization necessitate the use of integrated airborne data, namely Landsat ...
Oluwatoyin Khadijat Olomo   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

A new coinductive confluence proof for infinitary lambda calculus

open access: yes, 2020
We present a new and formal coinductive proof of confluence and normalisation of B\"ohm reduction in infinitary lambda calculus. The proof is simpler than previous proofs of this result.
Czajka, Łukasz
core   +1 more source

Isotopic characteristics of the Garonne River and its tributaries [PDF]

open access: yes, 2009
The Garonne is the largest river in the south-west of France, and its drainage basin stretches between the Pyrenees and the Massif Central mountains. Until now, no water stable isotope study has been performed on the whole Garonne river basin which is ...
Amiotte-Suchet   +35 more
core   +3 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Confluence and the Neo-Victorian in Dickensian

open access: yesÉtudes Britanniques Contemporaines, 2017
Charles Dickens's work is a favourite for screen and TV adaptations even though the latter tend to be deemed conservative. These adaptations however focus normally on one particular novel.
Armelle Parey
doaj   +1 more source

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