Results 41 to 50 of about 1,726 (292)
Selecciones Matemáticas, 2022 The objective of this article is to develop some results on conformable fractional derivatives, specifically the one known as Khalil’s conformable fractional derivative.
Jaime David Villacís Lascano +1 more
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Lie symmetry analysis of conformable differential equations
AIMS Mathematics, 2019 In this paper, we construct a proper extension of the classical prolongation formula of point transformations for conformable derivative. This technique is illustrated and employed to construct a symmetry group admitted by a conformable ordinary and ...
Youness Chatibi +2 more
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Solving Higher-Order Fractional Differential Equations by the Fuzzy Generalized Conformable Derivatives [PDF]
, 2021 Atimad Harir +2 more
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Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
A new conformable nabla derivative and its application on arbitrary time scales
Advances in Difference Equations, 2021 In this article, we introduce a new type of conformable derivative and integral which involve the time scale power function G ˆ η ( t , a ) $\widehat{\mathcal{G}}_{\eta }(t, a)$ for t , a ∈ T $t,a\in \mathbb{T}$ .
Mohamad Rafi Segi Rahmat +1 more
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