Results 61 to 70 of about 1,005,211 (317)

Stroma gene signature predicts responsiveness to chemotherapy in pancreatic ductal adenocarcinoma patient‐derived xenograft models

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma patient‐derived xenografts (PDAC‐PDXs) engrafted orthotopically in the pancreas of immunodeficient mice retain the main genetic and histopathological characteristics of the original human tumors. A 294 stroma gene signature differentiates between PDAC‐PDXs that are responsive to gemcitabine plus nab‐paclitaxel versus ...
Alessia Anastasia, Laura Formenti, Paola Ostano, Lucia Minoli, Andrea Resovi, Lavinia Morosi, Claudia Fioravanti, Edoardo Micotti, Cristina Matteo, Eugenio Scanziani, Giovanna Chiorino, Raffaella Giavazzi, Carmen Ghilardi, Dorina Belotti   +13 more
wiley   +1 more source

Nonrational Conformal Field Theory [PDF]

, 2009
We discuss the problem to develop a mathematical theory of a certain class of nonrational conformal field theories (CFT) which contain the unitary CFT. A variant of the concept of a modular functor is proposed that appears to be suitable for such CFT.
openaire   +3 more sources

Spin clusters and conformal field theory [PDF]

Journal of Statistical Mechanics: Theory and Experiment, 2013
We study numerically the fractal dimensions and the bulk three-point connectivity for the spin clusters of the Q-state Potts model in two dimensions with $1\leq Q\leq 4$. We check that the usually invoked correspondence between FK clusters and spin clusters works at the level of fractal dimensions.
Delfino, Gesualdo, Picco M, Santachiara R, Viti J.   +3 more
openaire   +5 more sources

Quantum impurity models from conformal field theory

Journal of High Energy Physics, 2019
The coupling between localized magnetic moments and itinerant electrons presents a plethora of interesting physics. The low-energy physics of some quantum impurity systems can be described using conformal field theory (CFT). In this paper, the connection
Ying-Hai Wu, Hong-Hao Tu
doaj   +1 more source

Conformal Bootstrap in Embedding Space [PDF]

Phys. Rev. D 93, 105047 (2016), 2016
It is shown how to obtain conformal blocks from embedding space with the help of the operator product expansion. The minimal conformal block originates from scalar exchange in a four-point correlation functions of four scalars. All remaining conformal blocks are simple derivatives of the minimal conformal block.
arxiv   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Spinning Conformal Blocks [PDF]

JHEP 1111 (2011) 154, 2011
For conformal field theories in arbitrary dimensions, we introduce a method to derive the conformal blocks corresponding to the exchange of a traceless symmetric tensor appearing in four point functions of operators with spin. Using the embedding space formalism, we show that one can express all such conformal blocks in terms of simple differential ...
arxiv   +1 more source

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

FEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo, Klaudia Jaczynska, Christian Rosenmund   +2 more
wiley   +1 more source

Supergravity Predictions on Conformal Field Theories [PDF]

Proceedings of Quantum aspects of gauge theories, supersymmetry and unification — PoS(tmr99), 2000
We give an update on recent results about the matching between CFT operators and KK states in the AdS/CFT correspondence, and add some new comments on the realization of the baryonic symmetries from the supergravity point of view.
CERESOLE A, DALL'AGATA, GIANGUIDO, D'AURIA R, FERRARA S.   +3 more
openaire   +5 more sources

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source