Results 91 to 100 of about 2,289,577 (361)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

A Formula of Packing Pressure of a Factor Map

Entropy, 2017
In this paper, using the notion of packing pressure, we show a formula of packing pressure of a factor map. We also give an application in conformal repellers.
Cao Zhao, Ercai Chen, Xiucheng Hong, Xiaoyao Zhou   +3 more
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Dipole-magnet field models based on a conformal map

Physical Review Special Topics. Accelerators and Beams, 2012
In general, generation of charged-particle transfer maps for conventional iron-pole-piece dipole magnets to third and higher order requires a model for the midplane field profile and its transverse derivatives (soft-edge model) to high order and ...
P. L. Walstrom
doaj   +1 more source

Selecting Map Projections in Minimizing Area Distortions in GIS Applications

Sensors, 2008
Varioussoftware for Geographical Information Systems (GISs) have been developed and used in many different engineering projects. In GIS applications, map coverage is important in terms of performing reliable and meaningful queries. Map projections can be
Ahmet Kaya, Faruk Yildirim
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Conformal Mapping on Rough Boundaries I: Applications to harmonic problems

, 2004
The aim of this study is to analyze the properties of harmonic fields in the vicinity of rough boundaries where either a constant potential or a zero flux is imposed, while a constant field is prescribed at an infinite distance from this boundary.
A. G. Voronovich, A. L. Barabási, B. B. Mandelbrot, B. B. Mandelbrot, B. L. Cox, B. Sapoval, B. Sapoval, B. Sapoval, B. Sapoval, C. Pozrikidis, C. Pozrikidis, C. Pozrikidis, D. M. Kulawansa, D. Vandembroucq and S. Roux, D. Vandembroucq. A. C. Boccara, Damien Vandembroucq, E. Bouchaud, F. M. Borodich, F. M. Borodich, H. Hasimoto, J. Feder, J. J. L. Higdon, J. Schmittbuhl, K. J. M̊aløy, L. Boyer, M. H. Gutknecht, M. H. Gutknecht, P. Henrici, P. Meakin, P. Meakin, P. Meakin, R. H. Dauskardt, R. W. Davidge, S. He, S. R. Brown, S. Roux, Stéphane Roux, T. C. Halsey, T. C. Halsey, T. C. Halsey, T. C. Halsey, T. Halpin-Healy, T. Vicsek   +42 more
core   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

The Best Conic Conformal Map Projection for the Territory of Croatia

Kartografija i Geoinformacije, 2010
The paper gives an answer to the question: if the maritime area of Croatia (territorial sea and continental shelf) is involved, which is the best Lambert conic conformal map projection for the territory of Croatia?
Marina Rajakovic, Miljenko Lapaine
doaj