Results 111 to 120 of about 1,593,652 (317)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

New method of calculating the wakefields of a point charge in a waveguide of arbitrary cross section

open access: yesPhysical Review Accelerators and Beams, 2016
A new method for calculating the Cherenkov wakefield acting on a point charged particle passing through a longitudinally homogeneous structure lined with layer(s) of an arbitrary retarding (dielectric, resistive, or corrugated) material has been ...
S. S. Baturin, A. D. Kanareykin
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Scattering by an Almost Circular Cylinder With Smooth Surface [PDF]

open access: yesJournal of Electrical and Electronics Engineering, 2008
The problem of finding the scattered and diffractedfields of a plane wave by an infinite cylinder witharbitrary cross section presents considerabledifficulty. We discuss a boundary perturbationmethod in which we conformally map the givenarbitrary surface
Simona Castrase, Apostolos Kokkosis
doaj  

An Improved Magnetic Equivalent Circuit Model for Electromagnetic Modeling of Electric Machines

open access: yesIranian Journal of Electrical and Electronic Engineering, 2021
Poor modeling of air-gap is the main defect of conventional magnetic equivalent circuit (CMEC) model for performance analysis of electric machines. This paper presents an improved magnetic equivalent circuit (IMEC) which considers all components of air ...
F. Rezaee-Alam   +2 more
doaj  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Modeling inline oscillating foils using periodic conformal mapping

open access: yesApplied Ocean Research
Inline oscillating foils can obtain hydrodynamic benefits by adequately maintaining their spacing and interacting with the oncoming wakes. Since the complexity increases with the group size, this work explores the hydrodynamic performance of in-phase ...
Wei-Kuo Yen, Derek A. Paley
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

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