Results 101 to 110 of about 2,919,673 (305)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
A conformal mapping method in inverse obstacle scattering
, 2014 Akduman, Haddar and Kress [Akduman I, Kress R. Electrostatic imaging via conformal mapping. Inverse Prob. 2002;18:1659–1672; Haddar H, Kress R. Conformal mappings and inverse boundary value problems. Inverse Prob. 2005;21:935–953; Kress R.
H. Haddar, R. Kress
semanticscholar +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Jixie qiangdu, 2019 In order to calculate the stress intensity factors of two-dimensional cracks emanating from elliptical hole, a solution method for stress intensity factor based on Muskhelishvili complex function theory and truncated conformal mapping approach is ...
ZHU QingYu, ZHOU Rui
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CONFORMAL MAPPING ANALYSIS OF VARIOUS COPLANAR WAVEGUIDE STRUCTURES [PDF]
ICTACT Journal on Communication Technology, 2012 A conformal mapping analysis of various coplanar waveguide structures is presented on silicon substrate. The analysis is based on quasi-TEM analysis which is used in formulating the electrical parameters of a transmission line.
B. Nataraj, K. Porkumaran
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The conformal gauge to the derivative gauge for worldsheet gravity
Physics Letters B, 2015 The BRST quantizations of worldsheet gravity corresponding to final more acceptable derivative gauge and the standard conformal gauge are studied. We establish a mapping between these two gauges utilizing FFBRST formulation in standard way. Therefore, we
Sudhaker Upadhyay
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
New method of calculating the wakefields of a point charge in a waveguide of arbitrary cross section
Physical Review Accelerators and Beams, 2016 A new method for calculating the Cherenkov wakefield acting on a point charged particle passing through a longitudinally homogeneous structure lined with layer(s) of an arbitrary retarding (dielectric, resistive, or corrugated) material has been ...
S. S. Baturin, A. D. Kanareykin
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