Results 81 to 90 of about 2,919,673 (305)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
A construction method for conformal mapping of the unit disk onto a Riemann surface
Учёные записки Казанского университета: Серия Физико-математические науки, 2018 A construction method for approximate conformal mapping of the unit disk onto a Riemann surface (a map with a self-overlapping image) has been described.
P.N. Ivanshin
doaj
An anomaly detection method for conformal mechanism
Egyptian Informatics JournalThis paper introduces a novel hypersphere-based anomaly detection method enhanced by a conformal mapping transformation to address challenges such as data sparsity, computational complexity, and the scarcity of labeled anomalies in high-dimensional ...
Jian Zheng +4 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
A mass-independent conformal quantum cloak
New Journal of Physics, 2017 An obstacle to constructing a quantum cloak with the transformation design method for steering a matter wave is the device involving the anisotropic modulation of the particle mass.
De-Hone Lin
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
FireThe evolution of a flame front in a channel was considered in a two-dimensional approximation. In the approximation of the potential flow of combustion products and unburned mixture, the formation of a finger-shaped flame was considered after ignition at
Sergey Golovastov
doaj +1 more source
The approximate conformal mapping onto multiply connected domains
Проблемы анализа, 2019 The method of boundary curve reparametrization is generalized to the case of multiply connected domains. We construct the approximate analytical conformal mapping of the unit disk with N circular slits or an annulus with (N - 1) circular slits onto an ...
Abzalilov, Shirokova
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source