Results 81 to 90 of about 10,836 (311)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

An anomaly detection method for conformal mechanism

open access: yesEgyptian Informatics Journal
This paper introduces a novel hypersphere-based anomaly detection method enhanced by a conformal mapping transformation to address challenges such as data sparsity, computational complexity, and the scarcity of labeled anomalies in high-dimensional ...
Jian Zheng   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

A domain decomposition method for conformal mapping onto a rectangle [PDF]

open access: yes, 1989
Let g be the function which maps conformally a simply-connected domain G onto a rectangle R so that four specified points z1, z2, z3, z4,o n ∂G are mapped respectively onto the four vertices of R.
Stylianopoulos, N S, Papamichael, N
core  

A construction method for conformal mapping of the unit disk onto a Riemann surface

open access: yesУчёные записки Казанского университета: Серия Физико-математические науки, 2018
A construction method for approximate conformal mapping of the unit disk onto a Riemann surface (a map with a self-overlapping image) has been described.
P.N. Ivanshin
doaj  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

A numerical method for the computation of faber polynomials for starlike domains [PDF]

open access: yes, 1991
We describe a simple numerical process (based on the Theodorsen method for conformal mapping ) for computing approximations to Faber polynomials for starlike ...
Soares, M J   +2 more
core  

A mass-independent conformal quantum cloak

open access: yesNew Journal of Physics, 2017
An obstacle to constructing a quantum cloak with the transformation design method for steering a matter wave is the device involving the anisotropic modulation of the particle mass.
De-Hone Lin
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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