Results 71 to 80 of about 2,919,673 (305)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Journal of High Energy Physics, 2019 We show that the simplest FLRW cosmological system consisting in the homo- geneous and isotropic massless Einstein-Scalar system enjoys a hidden conformal symmetry under the 1D conformal group SL(2, ℝ) acting as Mobius transformations in proper time ...
Jibril Ben Achour, Etera R. Livine
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Conformal Mappings of Mixed Generalized Quasi-Einstein Manifolds Admitting Special Vector Fields
Extracta Mathematicae, 2017 It is known that Einstein manifolds form a natural subclass of the class of quasi-Einstein manifolds and plays an important role in geometry as well as in general theory of relativity.
S. Dey, A. Bhattacharyya
doaj
Inhomogeneous dielectrics: conformal mapping and finite-element models
Open Physics, 2017 Field singularities in electrostatic and magnetostatic fields require special attention in field calculations, and today finite element methods are normally used, both in homogeneous and in inhomogeneous dielectric cases.
Costamagna Eugenio, Barba Paolo Di
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Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
PROSPECTS OF WIDER USE OF THE OF COMPLEMENTARITY AND CONGRUENCE CONCEPT IN PRACTICAL MEDICINE
Medična Informatika ta Inženerìâ, 2015 It was discussed the possibility of widespread use of the complementarity and congruence concepts in medicine. It is proposed to use a simple functional to formalize therapeutic strategy is a reflection of the diagnostic and follow-conformal mapping ...
O. P. Mintser, L. Yu. Babintseva
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FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source