Results 111 to 120 of about 2,919,673 (305)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Scattering by an Almost Circular Cylinder With Smooth Surface [PDF]

open access: yesJournal of Electrical and Electronics Engineering, 2008
The problem of finding the scattered and diffractedfields of a plane wave by an infinite cylinder witharbitrary cross section presents considerabledifficulty. We discuss a boundary perturbationmethod in which we conformally map the givenarbitrary surface
Simona Castrase, Apostolos Kokkosis
doaj  

An Improved Magnetic Equivalent Circuit Model for Electromagnetic Modeling of Electric Machines

open access: yesIranian Journal of Electrical and Electronic Engineering, 2021
Poor modeling of air-gap is the main defect of conventional magnetic equivalent circuit (CMEC) model for performance analysis of electric machines. This paper presents an improved magnetic equivalent circuit (IMEC) which considers all components of air ...
F. Rezaee-Alam   +2 more
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Hawking-Page and entanglement phase transition in 2d CFT on curved backgrounds

open access: yesJournal of High Energy Physics
The thermodynamics and the entanglement properties of two-dimensional conformal field theories (2d CFTs) on curved backgrounds are studied. By means of conformal mapping we study the equivalent system on flat space governed by the deformed Hamiltonian ...
Akihiro Miyata   +3 more
doaj   +1 more source

Modeling inline oscillating foils using periodic conformal mapping

open access: yesApplied Ocean Research
Inline oscillating foils can obtain hydrodynamic benefits by adequately maintaining their spacing and interacting with the oncoming wakes. Since the complexity increases with the group size, this work explores the hydrodynamic performance of in-phase ...
Wei-Kuo Yen, Derek A. Paley
doaj   +1 more source

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