Results 31 to 40 of about 276,514 (189)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Head and neck cancer in young adults treated with 3-D conformal radiotherapy [PDF]

Archive of Oncology, 2010
Background: Purpose of this study was to determine patterns of failure in young adults with head and neck cancer treated with 3-D conformal radiotherapy.
Stojkovski Igor, Krstevska Valentina, Mitreski Nenad, Stojkovska Eleonora, Simonova Daniela   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Intensity-modulated radiotherapy (IMRT) versus three-dimensional conformal radiotherapy (3DCRT) as treatment plans for head and neck tumours

Journal of the Pakistan Medical Association
Objectives: To compare intensity-modulated radiation therapy with three-dimensional conformal radiation therapy 3DCRTwith respect to dose coverage for target volume.
Abd Al-Taj Abd Ali Khaleel, Siham Sabah Abdullah, Sabbar Shukri Al-Bayaty, Nabaa Mohammad Ali Alazawy, Abdulrahman Mohammed Abdulbaqi   +4 more
doaj   +1 more source

Prognostic factors in radiotherapy of anaplastic thyroid carcinoma: a single center study over 31 years

Radiation Oncology, 2023
Background Anaplastic thyroid carcinoma has a very poor prognosis. We analyzed the effect of surgery, radiotherapy and chemotherapy on survival time and side effects in patients with ATC.
Julia Jacob, Dirk Vordermark, Kerstin Lorenz, Daniel Medenwald   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Conformational radiotherapy of no metastatic prostate cancer: Experience of the radiation therapy department of EHS Oncology Emir Abdelkader of Oran

Journal de la Faculté de Médecine d'Oran, 2022
Introduction - Over the last decades, prostate cancer has become a public health condition, due to its frequency and severity. The conformational radiotherapy constituted today the standard technique in the irradiation of non-metastatic prostate cancers
Lotfi TALEB, Karima CHENNI, Ismail Zergoug, Abdelbaki Boukerche, Ahmed Fethi Dali-Youcef   +4 more
doaj  

Adjuvant Radiotherapy with Three-Dimensional Conformal Radiotherapy of Lacrimal Gland Adenoid Cystic Carcinoma [PDF]

Journal of Clinical and Diagnostic Research, 2015
Background & Aim: Adenoid cystic carcinoma (ACC) of lacrimal gland is a rare tumour with aggressive behaviour. There is sparse data to address optimum therapy for such tumours.
Vikas Roshan, Sushmita Pathy, Supriya Mallick, Subhash Chander, Seema Sen, Bhavna Chawla   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Salvage conformal radiotherapy for biochemical recurrent prostate cancer after radical prostatectomy

International Brazilian Journal of Urology, 2006
OBJECTIVE: Assess the results of salvage conformal radiotherapy in patients with biochemical failure after radical prostatectomy and identify prognostic factors for biochemical recurrence and toxicity of the treatment.
Carlos R. Monti, Ricardo A. Nakamura, Robson Ferrigno, Aristides Rossi Jr, Neusa S. Kawakami, Felipe A. Trevisan   +5 more
doaj   +1 more source