Results 41 to 50 of about 276,514 (189)

A prospective, comparative analysis of acute toxicity profile between three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) in locally advanced head and neck cancer patients

Cancer Treatment and Research Communications, 2020
Introduction: The advances of modern radiotherapy have emerged with the development of conformal radiotherapy techniques, such as the three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT).
Nilesh Kucha, Tej Prakash Soni, Naresh Jakhotia, Nidhi Patni, Dinesh Kumar Singh, Anil Kumar Gupta, Lalit Mohan Sharma, Jaishree Goyal   +7 more
doaj   +1 more source

Spectrum of Imaging Patterns of Lung Cancer following Radiation Therapy

Diagnostics, 2023
Radiation therapy using conventional or newer high-precision dose techniques, including three-dimensional conformal radiotherapy, intensity-modulated radiation therapy, stereotactic body radiation therapy, four-dimensional conformational radiotherapy ...
Taylor A. Strange, Lauren T. Erasmus, Jitesh Ahuja, Rishi Agrawal, Girish S. Shroff, Mylene T. Truong, Chad D. Strange   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Concurrent Hypofractionated Three-dimensional Re-irradiation and Temozolomide in Recurrent Malignant Glioma

Middle East Journal of Cancer, 2012
Background: This study determines the efficacy and tolerability of hypofractionated three-dimensional conformal radiotherapy in conjunction with daily temozolomide in treatment of previously irradiated recurrent malignant glioma.Methods: We enrolled 21 ...
Doaa Ali Sharaf Eldeen, Eman Abd Elkareem Toson, Maiy Abd Elraheem Alshahat, Ahmed Nageeb Taha   +3 more
doaj  

Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma in Patients Unfit for Resection, Ablation, or Chemotherapy: A Retrospective Study

The Scientific World Journal, 2013
Purpose. The purpose is to evaluate the feasibility, efficacy, and the toxicity of three-dimensional conformal radiotherapy (3DCRT) in patients with advanced hepatocelluar carcinoma (HCC) and inferior vena cava tumor thrombosis (IVCTT). Methods.
Vassilis Kouloulias, Eftychia Mosa, John Georgakopoulos, Kalliopi Platoni, Ilias Brountzos, Anna Zygogianni, Christos Antypas, Paraskevas Kosmidis, Kyriaki Mystakidou, Maria Tolia, Ivelina Beli, Athanasios Gouliamos, John Kouvaris, Nikoalos Kelekis   +13 more
doaj   +1 more source

Three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy in carcinoma cervix

Journal of Clinical and Scientific Research, 2018
Background: Cervical cancer is the most common gynecological cancer among Indian women. 3D-CRT treatment is associated with more acute and late toxicities, because of close proximity of bladder and rectum to the cervix.
Revathi Badiginchala, Swapna Jilla, B V Subramanian, Prana Bandhu Das, Archana Prathipati, G Sanjeeva Kumar   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Dosimetric consequences of the shift towards computed tomography guided target definition and planning for breast conserving radiotherapy

Radiation Oncology, 2008
Background The shift from conventional two-dimensional (2D) to three-dimensional (3D)-conformal target definition and dose-planning seems to have introduced volumetric as well as geometric changes.
Korevaar Erik W, Maduro John H, Dolsma Wil V, van der Laan Hans, Langendijk Johannes A   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

External beam accelerated partial breast irradiation: dosimetric assessment of conformal and three different intensity modulated techniques

Radiology and Oncology, 2019
The aim of the study was to evaluate and compare four different external beam radiotherapy techniques of accelerated partial breast irradiation (APBI) considering target coverage, dose to organs at risk and overall plan quality.
Stelczer Gábor, Major Tibor, Mészáros Norbert, Polgár Csaba, Pesznyák Csilla   +4 more
doaj   +1 more source