Results 121 to 130 of about 663,489 (316)
Protein-Ligand Interactions: Docking, Design and Conformation Change [PDF]
, 2003 Virtual ligand screening has proven to be a successful strategy in drug design. An in house-developed procedure (HierDock), a coarse grain docking method followed by a fine grain search procedure, was used to determine the binding site for sugars in the
Datta, Deepshikha
core +1 more source
Beilstein Journal of Organic Chemistry, 2017 Fluorinated moieties are highly valuable to chemists due to the sensitive NMR detectability of the 19F nucleus. Fluorination of molecular scaffolds can also selectively influence a molecule’s polarity, conformational preferences and chemical reactivity ...
Vladimir Kubyshkin, Nediljko Budisa
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
evanfeinberg/conformation: v0.1 Alpha Release
, 2016 <p>Utilities for connecting molecular dynamics and experimental datasets with the power of machine learning.</p ...
Vijay S. Pande +2 more
core +1 more source
RESEARCH CONCERNING MORPHO CHARACTERISTICS OF ROMANIAN BLACK SPOTTED BREEDED IN CONDITION OF S.C. BIOTERA FARM, ALBA COUNTY [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2013 Researches regarding morpho characteristics of Romanian Black Spotted breed were performed on 56 cows bull daughters in testing and candidate as bull's mother, raised and exploited in SC Biotera SRL farm from Alba county and has as database, records of ...
Alin AVRAM +2 more
doaj
Silyl-protective groups influencing the reactivity and selectivity in glycosylations
Beilstein Journal of Organic Chemistry, 2017 Silyl groups such as TBDPS, TBDMS, TIPS or TMS are well-known and widely used alcohol protective groups in organic chemistry. Cyclic silylene protective groups are also becoming increasingly popular. In carbohydrate chemistry silyl protective groups have
Mikael Bols, Christian Marcus Pedersen
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Conformation of Circular DNA in Two Dimensions
The conformation of circular DNA molecules of various lengths adsorbed in a 2D conformation on a mica surface is studied. The results confirm the conjecture that the critical exponent ν is topologically invariant and equal to the self-avoiding walk value
Witz, Guillaume +3 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2014 Structural studies of pentapeptides containing an achiral block, built from two dehydroamino acid residues (ΔZPhe and ΔAla) and two glycines, as well as one chiral L-Val residue were performed using NMR spectroscopy.
Michał Jewgiński +4 more
doaj +1 more source
Molecules, 2015 3-Aminomethylation of salicylalkylamides afforded hybrids with a Mannich base. In addition, it triggered the rotation of the amide bond. The observed conformational switch is driven by strong intramolecular hydrogen bonding between the Mannich base and ...
Christian Dank +7 more
doaj +1 more source