Results 131 to 140 of about 663,489 (316)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Conformation-Activity Mechanism of Alcalase Hydrolysis for Reducing In Vitro Allergenicity of Instant Soy Milk Powder

Effective reduction of the allergenicity of instant soy milk powder (ISMP) is practically valuable for expanding its applications. This study optimized the enzymolysis technology of ISMP using single-factor experiments and response surface methodology ...
Chunyan Zhu (295635), Shan Shang (17373678), Libo Qi (18449951), Limin Zhong (10274340), Songyi Lin (2544166), Jie Ding (73711)   +5 more
core   +1 more source

Conformation-Dependent Coordination of Carboxylic Acids with Fe₃O₄ Nanoparticles Studied by ATR-FTIR Spectral Deconvolution

, 2019
The coordination of valeric acid (VA), glutaric acid (GA), and tricarballylic acid (TA) with Fe–OH on the Fe3O4 nanoparticle surface has been systematically studied to elucidate the effects of COOH, molecular configuration, and ligand concentration on ...
Dexing Li (1817470), Guanglu Ge, Xiaoping Liu (240534), Dexing Li, Xiaoping Liu, Xiaorui Zhang, Renxiao Liu (2847500), Lan Chen (16760), Xiaorui Zhang (5196983), Lan Chen, Li Yuan (102305), Guanglu Ge (2847503), Renxiao Liu, Li Yuan   +13 more
core   +1 more source

Isoleucine gate blocks K+ conduction in C-type inactivation

eLife
Many voltage-gated potassium (Kv) channels display a time-dependent phenomenon called C-type inactivation, whereby prolonged activation by voltage leads to the inhibition of ionic conduction, a process that involves a conformational change at the ...
Werner Treptow, Yichen Liu, Carlos AZ Bassetto, Bernardo I Pinto, Joao Antonio Alves Nunes, Ramon Mendoza Uriarte, Christophe J Chipot, Francisco Bezanilla, Benoit Roux   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Conformation-Dependent Monolayer and Bilayer Structures of an Alkylated TTF Derivative Revealed using STM and Molecular Modeling

In this study, the multilayer self-assembled molecular network formation of an alkylated tetrathiafulvalene compound is studied at the liquid–solid interface between 1-phenyloctane and graphite.
Andrea Minoia (1894192), Kunal S. Mali (1455109), Catarina L. Delfino (17395050), Sandra Van Aert (7547783), Yansong Hao (1396180), Cristina Martin (1698814), Elumalai Gopi (1763356), Mark Van der Auweraer (1475641), Yves Henri Geerts (1864393), Steven De Feyter (7345211), Roberto Lazzaroni (1449016)   +10 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Contributions to Conformable and non-Conformable Calculus

, 2019
In this work, we introduce a definition of a local fractional derivative and a fractional integral of order alfa > 0 (where this parameter does not need to be integer), with which we overcome some deficiencies of known local derivatives, conformable or not. This definition allows to compute fractional derivatives of functions defined on any open set on
openaire   +3 more sources

On hydrodynamic methods for the analysis of the sizes and shapes of polysaccharides in dilute solution: a short review

, 2014
Polysaccharides and their derivatives are increasingly being used by the food, cosmetic and pharmaceutical industries: physical properties like size and conformation are important contributors to their performance. Here the use of hydrodynamic tools such
Harding, Stephen E., Adams, G. G., Morris, Gordon, Morris, Gordon A., Adams, Gary G., Harding, S. E.   +5 more
core   +1 more source