Results 141 to 150 of about 1,518,966 (331)

RESEARCH CONCERNING MORPHO CHARACTERISTICS OF ROMANIAN BLACK SPOTTED BREEDED IN CONDITION OF S.C. BIOTERA FARM, ALBA COUNTY [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2013
Researches regarding morpho characteristics of Romanian Black Spotted breed were performed on 56 cows bull daughters in testing and candidate as bull's mother, raised and exploited in SC Biotera SRL farm from Alba county and has as database, records of ...
Alin AVRAM, Gheorghe MURESAN, Eugen JURCO   +2 more
doaj  

Silyl-protective groups influencing the reactivity and selectivity in glycosylations

Beilstein Journal of Organic Chemistry, 2017
Silyl groups such as TBDPS, TBDMS, TIPS or TMS are well-known and widely used alcohol protective groups in organic chemistry. Cyclic silylene protective groups are also becoming increasingly popular. In carbohydrate chemistry silyl protective groups have
Mikael Bols, Christian Marcus Pedersen
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Morphometric measurements and animal-performance indices in a study of racial forms of Brazilian Sport Horses undergoing training for eventing

Revista Brasileira de Zootecnia
This study aimed to evaluate, in a practical manner, the use of linear and angular measurements and different animal-performance indices in a study on the breed-specific conformation of Brazilian Sport Horses training for eventing.
Felipe Gomes Ferreira Padilha, Agnaldo Machado de Andrade, Ana Beatriz Monteiro Fonseca, Fernanda Nascimento de Godoi, Fernando Queiroz de Almeida, Ana Maria Reis Ferreira   +5 more
doaj   +1 more source

Conformation of dehydropentapeptides containing four achiral amino acid residues – controlling the role of L-valine

Beilstein Journal of Organic Chemistry, 2014
Structural studies of pentapeptides containing an achiral block, built from two dehydroamino acid residues (ΔZPhe and ΔAla) and two glycines, as well as one chiral L-Val residue were performed using NMR spectroscopy.
Michał Jewgiński, Joanna Krzciuk-Gula, Maciej Makowski, Rafał Latajka, Paweł Kafarski   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Isoleucine gate blocks K+ conduction in C-type inactivation

eLife
Many voltage-gated potassium (Kv) channels display a time-dependent phenomenon called C-type inactivation, whereby prolonged activation by voltage leads to the inhibition of ionic conduction, a process that involves a conformational change at the ...
Werner Treptow, Yichen Liu, Carlos AZ Bassetto, Bernardo I Pinto, Joao Antonio Alves Nunes, Ramon Mendoza Uriarte, Christophe J Chipot, Francisco Bezanilla, Benoit Roux   +8 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source