Results 51 to 60 of about 1,518,966 (331)
Antibody Fragments Defining Biologically Relevant Conformations of Target Proteins
Antibodies, 2014 Antibody fragments have long been used as chaperones in crystallography, but have more recently been applied to the definition of biologically relevant conformations among the dynamic ensemble of target protein conformational sampling. This review charts
Alastair D. G. Lawson
doaj +1 more source
Highly Improved Electrospray Ionization-Mass Spectrometry Detection of G-Quadruplex-Folded Oligonucleotides and Their Complexes with Small Molecules [PDF]
, 2017 G-quadruplexes are nucleic acids structures stabilized by physiological concentration of potassium ions. Because low stability G-quadruplexes are hardly detectable by mass spectrometry, we optimized solvent conditions: isopropanol in a triethylamine ...
Scalabrin, Matteo +2 more
core +1 more source
Investigation of the Ergopeptide Epimerization Process
Computation, 2014 Ergopeptides, like ergocornine and a-ergocryptine, exist in an S- and in an R-configuration. Kinetic experiments imply that certain configurations are preferred depending on the solvent. The experimental methods are explained in this article. Furthermore,
Karsten Andrae +6 more
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Frontiers in Nutrition, 2023 IntroductionProtein gelation process is of importance in food industry. The objective of this study is to investigate the influence of salt concentration variation, which induced protein conformation change, on protein’s intermolecular interactions and ...
Fuge Niu +6 more
doaj +1 more source
Mechano-transduction: from molecules to tissues. [PDF]
, 2014 External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R +3 more
core +2 more sources
Conformal Connections and Conformal Transformations [PDF]
Transactions of the American Mathematical Society, 1959 Introduction. In the previous paper [5], we have studied the groups of projective transformations of affinely connected manifolds by the application of the theory of normal projective connections. The main purpose of the present paper is to study the conformal properties of complete Riemannian spaces of some special type by the application of the ...
openaire +2 more sources
Identification of Plk1 type II inhibitors by structure-based virtual screening [PDF]
, 2009 Protein kinases are targets for drug development. Dysregulation of kinase activity leads to various diseases, e.g. cancer, inflammation, diabetes. Human polo-like kinase 1 (Plk1), a serine/threonine kinase, is a cancer-relevant gene and a potential drug ...
Keppner, Sarah +3 more
core +1 more source
Dependence of single-molecule junction conductance on molecular conformation [PDF]
Nature, 2006 Since it was first suggested that a single molecule might function as an active electronic component, a number of techniques have been developed to measure the charge transport properties of single molecules.
L. Venkataraman +4 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees ...
Annemieke Littooij +11 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Adolescent siblings of children with cancer are at elevated risk for psychosocial problems. Unfortunately, various barriers such as limited family time and resources, conflicting schedules, and psychosocial staffing constraints at cancer centers hinder sibling access to support.
Christina M. Amaro +10 more
wiley +1 more source