Phosphorylation-mediated conformational change regulates human SLFN11 [PDF]
Nature CommunicationsHuman Schlafen 11 (SLFN11) is sensitizing cells to DNA damaging agents by irreversibly blocking stalled replication forks, making it a potential predictive biomarker in chemotherapy.
Michael Kugler +4 more
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Conformational change in the chromatin remodelling protein MENT. [PDF]
PLoS ONE, 2009 Chromatin condensation to heterochromatin is a mechanism essential for widespread suppression of gene transcription, and the means by which a chromatin-associated protein, MENT, induces a terminally differentiated state in cells.
Poh Chee Ong +11 more
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The Conformational Change of the L3 Loop Affects the Structural Changes in the Substrate Binding Pocket Entrance of β-Glucosidase [PDF]
Molecules, 2023 β-glucosidase (Bgl) hydrolyzes cellobiose to glucose, thereby releasing non-reducing terminal glucosyl residues. Bgl is an essential enzyme belonging to the biomass-degrading enzyme family, which plays a vital role in enzymatic saccharification during ...
Ki Hyun Nam
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Modelling of conformational change within photosynthetic reaction center of Rb. sphaeroides bacteria [PDF]
Компьютерные исследования и моделирование, 2009 A possible conformational change, which accompanies electron tranport in Rb. sphaeroides photosynthetic reaction center (RC), was studied using quantum-chemical approach.
P. A. Mamonov +3 more
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Scientific Reports, 2023 Conformational changes play a key role in the biological function of many proteins, thereby sustaining a multitude of processes essential to life. Thus, the imaging of the conformational space of proteins exhibiting such conformational changes is of ...
Hannah Ochner +6 more
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MD Simulations Revealing Special Activation Mechanism of Cannabinoid Receptor 1
Frontiers in Molecular Biosciences, 2022 Cannabinoid receptor 1 (CB1) is a G protein-coupled receptor (GPCR) that is gaining much interest for its regulating role in the central nervous system and its value as a drug target.
Yiran Wu +8 more
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Protein conformational changes in the bacteriorhodopsin photocycle: comparison of findings from electron and X-ray crystallographic analyses. [PDF]
PLoS ONE, 2009 Light-driven conformational changes in the membrane protein bacteriorhodopsin have been studied extensively using X-ray and electron crystallography, resulting in the deposition of >30 sets of coordinates describing structural changes at various stages ...
Teruhisa Hirai, Sriram Subramaniam
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How to Distinguish Conformational Selection and Induced Fit Based on Chemical Relaxation Rates. [PDF]
PLoS Computational Biology, 2016 Protein binding often involves conformational changes. Important questions are whether a conformational change occurs prior to a binding event ('conformational selection') or after a binding event ('induced fit'), and how conformational transition rates ...
Fabian Paul, Thomas R Weikl
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Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis
eLife, 2022 Exocytosis of secretory vesicles requires the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins and small GTPase Rabs.
Tianzhi Li +3 more
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Frontiers in Microbiology, 2021 Rv3197 (MABP-1), a non-canonical ABC protein in Mycobacterium tuberculosis, has ATPase activity and confers inducible resistance to the macrolide family of antibiotics. Here we have shown that MSMEG_1954, the homolog of Rv3197 in M.
Qingqing Zhang +10 more
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