A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury [PDF]
Frontiers in Immunology, 2018 IntroductionC-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation.
Jan R. Thiele +16 more
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The Conformational Change of the L3 Loop Affects the Structural Changes in the Substrate Binding Pocket Entrance of β-Glucosidase [PDF]
Molecules, 2023 β-glucosidase (Bgl) hydrolyzes cellobiose to glucose, thereby releasing non-reducing terminal glucosyl residues. Bgl is an essential enzyme belonging to the biomass-degrading enzyme family, which plays a vital role in enzymatic saccharification during ...
Ki Hyun Nam
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Phosphorylation-mediated conformational change regulates human SLFN11 [PDF]
Nature CommunicationsHuman Schlafen 11 (SLFN11) is sensitizing cells to DNA damaging agents by irreversibly blocking stalled replication forks, making it a potential predictive biomarker in chemotherapy.
Michael Kugler +4 more
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Conformational change in the chromatin remodelling protein MENT. [PDF]
PLoS ONE, 2009 Chromatin condensation to heterochromatin is a mechanism essential for widespread suppression of gene transcription, and the means by which a chromatin-associated protein, MENT, induces a terminally differentiated state in cells.
Poh Chee Ong +11 more
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Modelling of conformational change within photosynthetic reaction center of Rb. sphaeroides bacteria [PDF]
Компьютерные исследования и моделирование, 2009 A possible conformational change, which accompanies electron tranport in Rb. sphaeroides photosynthetic reaction center (RC), was studied using quantum-chemical approach.
P. A. Mamonov +3 more
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Scientific Reports, 2023 Conformational changes play a key role in the biological function of many proteins, thereby sustaining a multitude of processes essential to life. Thus, the imaging of the conformational space of proteins exhibiting such conformational changes is of ...
Hannah Ochner +6 more
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Protein conformational changes in the bacteriorhodopsin photocycle: comparison of findings from electron and X-ray crystallographic analyses. [PDF]
PLoS ONE, 2009 Light-driven conformational changes in the membrane protein bacteriorhodopsin have been studied extensively using X-ray and electron crystallography, resulting in the deposition of >30 sets of coordinates describing structural changes at various stages ...
Teruhisa Hirai, Sriram Subramaniam
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Regulatory mechanisms triggered by enzyme interactions with lipid membrane surfaces
Frontiers in Molecular Biosciences, 2023 Recruitment of enzymes to intracellular membranes often modulates their catalytic activity, which can be important in cell signaling and membrane trafficking.
Jie Yu, David D. Boehr
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SPIN(DLY)-OFF: A tale of conformational change to control DYNEIN. [PDF]
J Cell Biol, 2022 Barbosa J, Sunkel CE, Conde C.
europepmc +3 more sources
How to Distinguish Conformational Selection and Induced Fit Based on Chemical Relaxation Rates. [PDF]
PLoS Computational Biology, 2016 Protein binding often involves conformational changes. Important questions are whether a conformational change occurs prior to a binding event ('conformational selection') or after a binding event ('induced fit'), and how conformational transition rates ...
Fabian Paul, Thomas R Weikl
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