An efficient approach for the calculation of frequencies in macromolecules [PDF]
, 2008 I. INTRODUCTION. Conformational changes of macromolecules are essential in the understanding of e.g. proteins and drug design. The theoretical prediction is far from trivial, especially for large molecules.
Brooks, Bernard R. +4 more
core
Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco +18 more
wiley +1 more source
Carbohydrate-protein interactions characterized by dual polarization hybrid plasmonic waveguide
Nanotechnology Reviews, 2018 Optical biosensors present good performance for the affinity analysis of a molecular binding event. However, most of those excited with single optical mode are “blind” to the conformational change of bound molecules.
Chen Chen, Hou Xun, Si Jinhai
doaj +1 more source
TRIP13 regulates DNA repair pathway choice through REV7 conformational change
Nature Cell Biology, 2020 Connor S. Clairmont +9 more
semanticscholar +1 more source
Transglutaminase 2 Undergoes a Large Conformational Change upon Activation
PLoS Biology, 2007 Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathogenesis of celiac sprue ...
D. Pinkas +3 more
semanticscholar +1 more source
Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen +18 more
wiley +1 more source
A FRET-Based Sensor Reveals Large ATP Hydrolysis–Induced Conformational Changes and Three Distinct States of the Molecular Motor Myosin [PDF]
, 2000 William M. Shih +3 more
openalex +1 more source
, 2011 In this paper we explore relevant electrical properties of two olfactory receptors (ORs), one from rat OR I7 and the other from human OR 17-40, which are of interest for the realization of smell nanobiosensors.
Alfinito, E. +2 more
core +1 more source
Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source
Conformational Changes in the Integrin औA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement [PDF]
, 2003 A. Paul Mould +6 more
openalex +1 more source