Results 11 to 20 of about 14,468,474 (325)
A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease. [PDF]
PLoS Pathogens, 2017 The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages by host and viral proteases in order to produce the individual proteins that constitute an infectious virion.
Matthew Brecher +9 more
doaj +2 more sources
Structural mechanism of a drug-binding process involving a large conformational change of the protein target. [PDF]
Nat Commun, 2023 Proteins often undergo large conformational changes when binding small molecules, but atomic-level descriptions of such events have been elusive. Here, we report unguided molecular dynamics simulations of Abl kinase binding to the cancer drug imatinib ...
Ayaz P +9 more
europepmc +2 more sources
Charge environments around phosphorylation sites in proteins [PDF]
, 2008 Background: Phosphorylation is a central feature in many biological processes. Structural analyses have identified the importance of charge-charge interactions, for example mediating phosphorylation-driven allosteric change and protein binding to ...
Kitchen, James +2 more
core +2 more sources
eLife, 2020 Mammalian mitochondrial inner membrane fusion is mediated by optic atrophy 1 (OPA1). Under physiological conditions, OPA1 undergoes proteolytic processing to form a membrane-anchored long isoform (L-OPA1) and a soluble short isoform (S-OPA1).
Danyang Zhang +8 more
doaj +1 more source
Conformational aspects of polymorphs and phases of 2-propyl-1H-benzimidazole
IUCrJ, 2018 This paper reports on the polymorphism of 2-propyl-1H-benzimidazole (2PrBzIm) induced by temperature change. Upon heating, an irreversible reconstructive-type phase transition at T = 384 K from the ordered form I (P212121) to a new polymorph, form IIHT ...
Fco. Javier Zuñiga +9 more
doaj +1 more source
Side-chain conformational changes upon protein-protein association [PDF]
, 2010 Conformational changes upon protein-protein association are the key element of the binding mechanism. The study presents a systematic large-scale analysis of such conformational changes in the side chains.
Kirys, Tatsiana +3 more
core +2 more sources
Structural Changes in the Cap of Rv0183/mtbMGL Modulate the Shape of the Binding Pocket
Biomolecules, 2021 Tuberculosis continues to be a major threat to the human population. Global efforts to eradicate the disease are ongoing but are hampered by the increasing occurrence of multidrug-resistant strains of Mycobacterium tuberculosis.
Christoph Grininger +6 more
doaj +1 more source
De novo design of tunable, pH-driven conformational changes
Science, 2019 Designed to respond Protein design has achieved success in finding sequences that fold to very stable target structures. Protein function, however, often requires conformational dynamics. Boyken et al.
Scott E. Boyken +20 more
openalex +3 more sources
Regulatory mechanisms triggered by enzyme interactions with lipid membrane surfaces
Frontiers in Molecular Biosciences, 2023 Recruitment of enzymes to intracellular membranes often modulates their catalytic activity, which can be important in cell signaling and membrane trafficking.
Jie Yu, David D. Boehr
doaj +1 more source
PLoS Computational Biology, 2019 The fungal circadian clock photoreceptor Vivid (VVD) contains a photosensitive allosteric light, oxygen, voltage (LOV) domain that undergoes a large N-terminal conformational change.
Hongyu Zhou +4 more
doaj +1 more source