The differing effects of a dual acting regulator on SIRT1
Frontiers in Molecular Biosciences, 2023 SIRT1 is an NAD+-dependent protein deacetylase that has been shown to play a significant role in many biological pathways, such as insulin secretion, tumor formation, lipid metabolism, and neurodegeneration.
Yujin Hur +11 more
doaj +1 more source
Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment [PDF]
, 2015 Bacterial -2-macroglobulins have been suggested to function in defence as broad-spectrum inhibitors of host proteases that breach the outer membrane.
Burchmore, R.J.S. +9 more
core +2 more sources
Investigation of Structural Dynamics of Enzymes and Protonation States of Substrates Using Computational Tools. [PDF]
, 2016 This review discusses the use of molecular modeling tools, together with existing experimental findings, to provide a complete atomic-level description of enzyme dynamics and function.
Chang, Chia-En A +3 more
core +2 more sources
A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]
, 2015 The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego +3 more
core +1 more source
A putative ATPase mediates RNA transcription and capping in a dsRNA virus
eLife, 2015 mRNA transcription in dsRNA viruses is a highly regulated process but the mechanism of this regulation is not known. Here, by nucleoside triphosphatase (NTPase) assay and comparisons of six high-resolution (2.9–3.1 Å) cryo-electron microscopy structures ...
Xuekui Yu +3 more
doaj +1 more source
Influence of pH on mechanical relaxations in high solids lm-pectin preparations [PDF]
, 2015 The influence of pH on the mechanical relaxation of LM-pectin in the presence of co-solute has been investigated by means of differential scanning calorimetry, ζ-potential measurements and small deformation dynamic oscillation in shear.
Al-Ruqaie +42 more
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Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer [PDF]
, 2016 The dynamic properties of foldamers, synthetic molecules that mimic folded biomolecules, have mainly been explored in free solution.We report on the design, synthesis, and conformational behavior of photoresponsive foldamers bound in a phospholipid ...
Clayden, Jonathan +5 more
core +3 more sources
Journal of Cell Biology, 1999 Here we report that in staurosporine-induced apoptosis of HeLa cells, Bid, a BH3 domain containing protein, translocates from the cytosol to mitochondria.
S. Desagher +8 more
semanticscholar +1 more source
Biophysics and Physicobiology, 2019 Structural changes of proteins are closely related with their molecular function. We previously developed a computational tool, Motion Tree (MT), to compare protein structures and describe structural changes using solely the Cα atoms.
Ryotaro Koike, Motonori Ota
doaj +1 more source
High temperature sensitivity is intrinsic to voltage-gated potassium channels
eLife, 2014 Temperature-sensitive transient receptor potential (TRP) ion channels are members of the large tetrameric cation channels superfamily but are considered to be uniquely sensitive to heat, which has been presumed to be due to the existence of an ...
Fan Yang, Jie Zheng
doaj +1 more source