Results 31 to 40 of about 14,468,474 (325)

Subtle pH differences trigger single residue motions for moderating conformations of calmodulin [PDF]

, 2011
This study reveals the essence of ligand recognition mechanisms by which calmodulin (CaM) controls a variety of Ca2+ signaling processes. We study eight forms of calcium-loaded CaM each with distinct conformational states.
Ali Rana Atilgan, Ayse Ozlem Aykut, Canan Atilgan, Gao Z. H., Huang S. L., Huang S. L., Maune J. F., Wei J. W., Yun C. H.   +8 more
core   +1 more source

Conformational preludes to the latency transition in PAI-1 as determined by atomistic computer simulations and hydrogen/deuterium-exchange mass spectrometry

Scientific Reports, 2017
Both function and dysfunction of serine protease inhibitors (serpins) involve massive conformational change in their tertiary structure but the dynamics facilitating these events remain poorly understood.
Michael Petersen, Jeppe B. Madsen, Thomas J. D. Jørgensen, Morten B. Trelle   +3 more
doaj   +1 more source

Selective modulation of cellular voltage dependent calcium channels by hyperbaric pressure - a suggested HPNS partial mechanism

Frontiers in Cellular Neuroscience, 2014
Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1MPa) and above, considered to be the result of synaptic transmission alteration ...
Ben eAviner, Gideon eGradwohl, Merav eMor Aviner, Shiri eLevy, Yoram eGrossman   +4 more
doaj   +1 more source

Global conformational dynamics of a Y-family DNA polymerase during catalysis. [PDF]

PLoS Biology, 2009
Replicative DNA polymerases are stalled by damaged DNA while the newly discovered Y-family DNA polymerases are recruited to rescue these stalled replication forks, thereby enhancing cell survival.
Cuiling Xu, Brian A Maxwell, Jessica A Brown, Likui Zhang, Zucai Suo   +4 more
doaj   +1 more source

Conformational selection in protein binding and function

, 2014
Protein binding and function often involves conformational changes. Advanced NMR experiments indicate that these conformational changes can occur in the absence of ligand molecules (or with bound ligands), and that the ligands may 'select' protein ...
Paul, Fabian, Weikl, Thomas R.
core   +1 more source

Structure and conformational change of a replication protein A heterotrimer bound to ssDNA.

Genes & Development, 2012
Replication protein A (RPA) is the main eukaryotic ssDNA-binding protein with essential roles in DNA replication, recombination, and repair. RPA maintains the DNA as single-stranded and also interacts with other DNA-processing proteins, coordinating ...
Jie Fan, N. Pavletich
semanticscholar   +1 more source

Chloride Ion Transport by the E. coli CLC Cl−/H+ Antiporter: A Combined Quantum-Mechanical and Molecular-Mechanical Study

Frontiers in Chemistry, 2018
We performed steered molecular dynamics (SMD) and umbrella sampling simulations of Cl− ion migration through the transmembrane domain of a prototypical E.
Chun-Hung Wang, Adam W. Duster, Baris O. Aydintug, MacKenzie G. Zarecki, Hai Lin   +4 more
doaj   +1 more source

Maximum Flux Transition Paths of Conformational Change

, 2010
Given two metastable states A and B of a biomolecular system, the problem is to calculate the likely paths of the transition from A to B. Such a calculation is more informative and more manageable if done for a reduced set of collective variables chosen ...
Berkowitz M., Bolhuis P. G., Bolhuis P. G., Brooks B. R., Brooks B. R., Chu J., Crehuet R., E W., E W., E, W., Elber R., Essmann U., Frenkel D., Gan W., Huang H., Huo S., Jiménez A., Jorgensen W. L., Jónsson H., Lei M., Ma A., MacKerell A. D., Mackerell, Jr A. D., Maragliano L., Metzner P., Onsager L., Ozkirimli E., Ozkirimli E., Pan A. C., Park S., Phillips J. C., Ren W., Ryckaert J.-P., Schlitter J., Singhal N., Vanden-Eijnden E., Vanden-Eijnden E., Vanden-Eijnden E., Vanden-Eijnden E., Yang S., Zhang J.   +40 more
core   +1 more source

Kinetic Characterization and X-ray Structure of a Mutant of Haloalkane Dehalogenase with Higher Catalytic Activity and Modified Substrate Range [PDF]

, 1996
Conversion of halogenated aliphatics by haloalkane dehalogenase proceeds via the formation of a covalent alkyl-enzyme intermediate which is subsequently hydrolyzed by water.
Dijkstra, Bauke W.,, Heimeriks, Gaston J.,, Janssen, Dick B.,, Kalk, Kor H.,, Poelarends, Gerrit J.,, Ridder, Ivo S.,, Rink, Rick,, Schanstra, Joost P.,   +7 more
core   +3 more sources

Crystal structure of a MarR family protein from the psychrophilic bacterium Paenisporosarcina sp. TG-14 in complex with a lipid-like molecule

IUCrJ, 2021
MarR family proteins regulate the transcription of multiple antibiotic-resistance genes and are widely found in bacteria and archaea. Recently, a new MarR family gene was identified by genome analysis of the psychrophilic bacterium Paenisporosarcina sp ...
Jisub Hwang, Sun-Ha Park, Chang Woo Lee, Hackwon Do, Seung Chul Shin, Han-Woo Kim, Sung Gu Lee, Hyun Ho Park, Sunghark Kwon, Jun Hyuck Lee   +9 more
doaj   +1 more source