Results 41 to 50 of about 497,883 (326)
Protons induce calsequestrin conformational changes
Biophysical Journal, 1996 Calsequestrin, a high-capacity, intermediate-affinity, calcium-binding protein present in the lumen of sarcoplasmic reticulum, undergoes extensive calcium-induced conformational changes at neutral pH that cause distinct intrinsic fluorescence changes.
Hidalgo Tapia, María Cecilia +2 more
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Frontiers in Cellular Neuroscience, 2014 Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1MPa) and above, considered to be the result of synaptic transmission alteration ...
Ben eAviner +4 more
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IUCrJ, 2021 MarR family proteins regulate the transcription of multiple antibiotic-resistance genes and are widely found in bacteria and archaea. Recently, a new MarR family gene was identified by genome analysis of the psychrophilic bacterium Paenisporosarcina sp ...
Jisub Hwang +9 more
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Pressure-dependent 13C chemical shifts in proteins: Origins and applications [PDF]
, 2009 Pressure-dependent (13)C chemical shifts have been measured for aliphatic carbons in barnase and Protein G. Up to 200 MPa (2 kbar), most shift changes are linear, demonstrating pressure-independent compressibilities.
Akasaka, A. +3 more
core +1 more source
Parsimony in Protein Conformational Change [PDF]
Structure, 2015 Protein conformational change is analyzed by finding the minimalist backbone torsion angle rotations that superpose crystal structures within experimental error. Of several approaches for enforcing parsimony during flexible least-squares superposition, an ℓ(1)-norm restraint provided greatest consistency with independent indications of flexibility from
Chapman, Brynmor K. +4 more
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Frontiers in Chemistry, 2018 We performed steered molecular dynamics (SMD) and umbrella sampling simulations of Cl− ion migration through the transmembrane domain of a prototypical E.
Chun-Hung Wang +4 more
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T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation. [PDF]
PLoS ONE, 2008 How the T cell antigen receptor (TCR) discriminates between molecularly related peptide/Major Histocompatibility Complex (pMHC) ligands and converts this information into different possible signaling outcomes is still not understood.
Ruth M Risueño +2 more
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Allosteric activation of preformed EGF receptor dimers by a single ligand binding event
Frontiers in Endocrinology, 2022 Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated in a variety of human cancers. Elucidation of the structure of the full-length receptor is essential to understand the molecular mechanisms underlying its
Endang R. Purba +6 more
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Identifying conformational changes with site-directed spin labeling reveals that the GTPase domain of HydF is a molecular switch [PDF]
, 2017 [FeFe]-hydrogenases catalyse the reduction of protons to hydrogen at a complex 2Fe[4Fe4S] center called H-cluster. The assembly of this active site is a multistep process involving three proteins, HydE, HydF and HydG.
Acquasaliente, Laura +8 more
core +1 more source
Ca2+-based allosteric switches and shape shifting in RGLG1 VWA domain
Computational and Structural Biotechnology Journal, 2020 RGLG1 is an E3 ubiquitin ligase in Arabidopsis thaliana that participates in ABA signaling and regulates apical dominance. Here, we present crystal structures of RGLG1 VWA domain, revealing two novel calcium ions binding sites (NCBS1 and NCBS2 ...
Qin Wang +9 more
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