Results 41 to 50 of about 14,468,474 (325)

Pressure-dependent 13C chemical shifts in proteins: Origins and applications [PDF]

, 2009
Pressure-dependent (13)C chemical shifts have been measured for aliphatic carbons in barnase and Protein G. Up to 200 MPa (2 kbar), most shift changes are linear, demonstrating pressure-independent compressibilities.
Akasaka, A., Kitahara, R., Williamson, M.P., Wilton, D.J.   +3 more
core   +1 more source

TCR nanoclusters as the framework for transmission of conformational changes and cooperativity

Frontiers in Immunology, 2012
Increasing evidence favors the notion that, before triggering, the T cell antigen receptor (TCR) forms nanometer-scale oligomers that are called nanoclusters.
Raquel eBlanco, Balbino eAlarcon
doaj   +1 more source

T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation. [PDF]

PLoS ONE, 2008
How the T cell antigen receptor (TCR) discriminates between molecularly related peptide/Major Histocompatibility Complex (pMHC) ligands and converts this information into different possible signaling outcomes is still not understood.
Ruth M Risueño, Wolfgang W A Schamel, Balbino Alarcón   +2 more
doaj   +1 more source

Allosteric activation of preformed EGF receptor dimers by a single ligand binding event

Frontiers in Endocrinology, 2022
Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated in a variety of human cancers. Elucidation of the structure of the full-length receptor is essential to understand the molecular mechanisms underlying its
Endang R. Purba, Ei-ichiro Saita, Reetesh R. Akhouri, Lars-Goran Öfverstedt, Gunnar Wilken, Ulf Skoglund, Ichiro N. Maruyama   +6 more
doaj   +1 more source

Minimal Aggregate Size and Minimal Fusion Unit for the First Fusion Pore of Influenza Hemagglutinin-Mediated Membrane Fusion [PDF]

, 2000
The data of Melikyan et al. (J. Gen. Physiol. 106:783, 1995) for the time required for the first measurable step of fusion, the formation of the first flickering conductivity pore between influenza hemagglutinin (HA) expressing cells and planar bilayers,
Joe Bentz, Alford, Bentz, Bentz, Bentz, Bentz, Bentz, Bentz, Bentz, Blumenthal, Brandon, Brunner, Bullough, Carr, Carr, Chen, Chernomordik, Chernomordik, Chernomordik, Danieli, Dieckmann, Durell, Ellens, Epand, Gaudin, Godley, Gray, Gray, Hernandez, Körte, Körte, Kozlov, Markovic, Melikyan, Molski, Pak, Plonsky, Puri, Qiao, Razinkov, Razinkov, Ruigrok, Shangguan, Shangguan, Skehel, Skehel, Sosnick, Stegmann, Stegmann, Steinhauer, Torney, Tse, Weissenhorn, Wharton, White, Wilson, Yu, Zimmerberg   +57 more
core   +4 more sources

Ca2+-based allosteric switches and shape shifting in RGLG1 VWA domain

Computational and Structural Biotechnology Journal, 2020
RGLG1 is an E3 ubiquitin ligase in Arabidopsis thaliana that participates in ABA signaling and regulates apical dominance. Here, we present crystal structures of RGLG1 VWA domain, revealing two novel calcium ions binding sites (NCBS1 and NCBS2 ...
Qin Wang, YaYu Chen, ShengPing Li, WenDi Yang, LiFang Sun, MeiQin Jang, XiuLing Wu, QianChao Wang, Lifei Chen, YunKun Wu   +9 more
doaj   +1 more source

Identifying conformational changes with site-directed spin labeling reveals that the GTPase domain of HydF is a molecular switch [PDF]

, 2017
[FeFe]-hydrogenases catalyse the reduction of protons to hydrogen at a complex 2Fe[4Fe4S] center called H-cluster. The assembly of this active site is a multistep process involving three proteins, HydE, HydF and HydG.
Acquasaliente, Laura, Bortolus, Marco, Carbonera, Donatella, Costantini, Paola, DE FILIPPIS, Vincenzo, DE ROSA, Edith, Doni, Davide, Galazzo, Laura, Maso, Lorenzo   +8 more
core   +1 more source

A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury

Frontiers in Immunology, 2018
IntroductionC-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation.
Jan R. Thiele, Johannes Zeller, Jurij Kiefer, David Braig, Sheena Kreuzaler, Yvonne Lenz, Lawrence A. Potempa, Florian Grahammer, Florian Grahammer, Tobias B. Huber, Tobias B. Huber, Tobias B. Huber, M. Huber-Lang, Holger Bannasch, G. Björn Stark, Karlheinz Peter, Steffen U. Eisenhardt   +16 more
doaj   +1 more source

A network model to investigate structural and electrical properties of proteins

, 2007
One of the main trend in to date research and development is the miniaturization of electronic devices. In this perspective, integrated nanodevices based on proteins or biomolecules are attracting a major interest.
Alfinito E, Atilgan A R, Cecilia Pennetta, Debye P, Edérlyi A, Eleonora Alfinito, Fisher Weiss T, Kim M K, Lino Reggiani, McCammon A, Menon S T, Pennetta C, Pennetta C, Schlag E W, Taketomi H, Warshel A   +15 more
core   +1 more source

The Carboxyl-Terminal Segment of Apolipoprotein A-V Undergoes a Lipid-Induced Conformational Change [PDF]

, 2010
Apolipoprotein (apo) A-V is a 343-residue, multidomain protein that plays an important role in regulation of plasma triglyceride homeostasis. Primary sequence analysis revealed a unique tetraproline sequence (Pro293-Pro296) near the carboxyl terminus of ...
Lee, B. L., Mauldin, Kasuen, Oleszczuk, M., Ryan, R. O., Sykes, B. D.   +4 more
core   +2 more sources