Results 51 to 60 of about 497,883 (326)

Folding and unfolding of a triple-branch DNA molecule with four conformational states [PDF]

, 2011
Single-molecule experiments provide new insights into biological processes hitherto not accessible by measurements performed on bulk systems. We report on a study of the kinetics of a triple-branch DNA molecule with four conformational states by pulling ...
Anna Alemany, Felix Ritort, Forns N, Mossa A, Nuria Forns, Philipp Maass, Sandra Engel   +6 more
core   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

TCR nanoclusters as the framework for transmission of conformational changes and cooperativity

Frontiers in Immunology, 2012
Increasing evidence favors the notion that, before triggering, the T cell antigen receptor (TCR) forms nanometer-scale oligomers that are called nanoclusters.
Raquel eBlanco, Balbino eAlarcon
doaj   +1 more source

Conformational change of adenine nucleotide translocase‐1 mediates cisplatin resistance induced by EBV‐LMP1

EMBO Molecular Medicine, 2021
Adenine nucleotide translocase‐1 (ANT1) is an ADP/ATP transporter protein located in the inner mitochondrial membrane. ANT1 is involved not only in the processes of ADP/ATP exchange but also in the composition of the mitochondrial membrane permeability ...
Lin Zhao, Xiangying Deng, Yueshuo Li, Jianmin Hu, Longlong Xie, Feng Shi, Min Tang, Ann M Bode, Xin Zhang, Weihua Liao, Ya Cao   +10 more
doaj   +1 more source

A network model to investigate structural and electrical properties of proteins

, 2007
One of the main trend in to date research and development is the miniaturization of electronic devices. In this perspective, integrated nanodevices based on proteins or biomolecules are attracting a major interest.
Alfinito E, Atilgan A R, Cecilia Pennetta, Debye P, Edérlyi A, Eleonora Alfinito, Fisher Weiss T, Kim M K, Lino Reggiani, McCammon A, Menon S T, Pennetta C, Pennetta C, Schlag E W, Taketomi H, Warshel A   +15 more
core   +1 more source

Molecular dynamics as an approach to study prion protein misfolding and the effect of pathogenic mutations [PDF]

, 2011
Computer simulation of protein dynamics offers unique high-resolution information that complements experiment. Using experimentally derived structures of the natively folded prion protein (PrP), physically realistic dynamics and conformational changes ...
Daggett, Valerie, van der Kamp, Marc W
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating [PDF]

, 2011
We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal ...
Markhasin, V. S., Moskvin, A. S., Ryvkin, A. M., Solovyova, O. E.   +3 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Tailoring the Dynamics of Excited‐State Charge Transfer through Conformational Engineering to Improve Second Near‐Infrared Fluorescence for High‐Resolution Osteosarcoma Imaging

Small Structures
The dynamics of excited‐state charge transfer (CT) in second near‐infrared (NIR‐II) fluorophore proceeds with conformational change that govern fluorescence.
Minghui Li, Guojing Chen, Mingxuan Jia, Jie Zhang, Xiaofei Miao, Weiyun Yao, Yibo Fan, Yajie Lu, Xin Xiao, Quli Fan, Wenbo Hu, Jing Li   +11 more
doaj   +1 more source