Results 51 to 60 of about 14,468,474 (325)

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Folding and unfolding of a triple-branch DNA molecule with four conformational states [PDF]

, 2011
Single-molecule experiments provide new insights into biological processes hitherto not accessible by measurements performed on bulk systems. We report on a study of the kinetics of a triple-branch DNA molecule with four conformational states by pulling ...
Anna Alemany, Felix Ritort, Forns N, Mossa A, Nuria Forns, Philipp Maass, Sandra Engel   +6 more
core   +3 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Conformational Changes of Calmodulin on Calcium and Peptide Binding Monitored by Film Bulk Acoustic Resonators

Biosensors, 2011
Film bulk acoustic resonators (FBAR) are mass sensitive, label-free biosensors that allow monitoring of the interaction between biomolecules. In this paper we use the FBAR to measure the binding of calcium and the CaMKII peptide to calmodulin.
Janos Vörös, Johannes Ottl, Martin Nirschl   +2 more
doaj   +1 more source

Targeting N-Terminal Human Maltase-Glucoamylase to Unravel Possible Inhibitors Using Molecular Docking, Molecular Dynamics Simulations, and Adaptive Steered Molecular Dynamics Simulations

Frontiers in Chemistry, 2021
There are multiple drugs for the treatment of type 2 diabetes, including traditional sulfonylureas biguanides, glinides, thiazolidinediones, α-glucosidase inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase IV (DPP-4 ...
Shitao Zhang, Yi Wang, Lu Han, Xueqi Fu, Song Wang, Wannan Li, Weiwei Han   +6 more
doaj   +1 more source

Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating [PDF]

, 2011
We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal ...
Markhasin, V. S., Moskvin, A. S., Ryvkin, A. M., Solovyova, O. E.   +3 more
core   +3 more sources

Conformational selection or induced fit? 50 years of debate resolved

F1000 Biology Reports, 2011
Exactly 50 years ago, biochemists raised the question of the mechanism of the conformational change that mediates “allosteric” interactions between regulatory sites and biologically active sites in regulatory/receptor proteins.
J. Changeux, S. Edelstein
semanticscholar   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Tailoring the Dynamics of Excited‐State Charge Transfer through Conformational Engineering to Improve Second Near‐Infrared Fluorescence for High‐Resolution Osteosarcoma Imaging

Small Structures
The dynamics of excited‐state charge transfer (CT) in second near‐infrared (NIR‐II) fluorophore proceeds with conformational change that govern fluorescence.
Minghui Li, Guojing Chen, Mingxuan Jia, Jie Zhang, Xiaofei Miao, Weiyun Yao, Yibo Fan, Yajie Lu, Xin Xiao, Quli Fan, Wenbo Hu, Jing Li   +11 more
doaj   +1 more source

Study of the electrochemical behaviors of ion-binding to calmodulin

Journal of Hebei University of Science and Technology, 2017
In order to research the competitive binding with CaM between metal ions and Ca²⁺, electrochemical impedance spectroscopy (EIS) of ion (such as Ca²⁺,Cd²⁺,Al³⁺,Fe ...
Min CUI, Jujie REN, Junxin LI
doaj   +1 more source