Results 121 to 130 of about 3,449,175 (207)

Single-Molecule Conformational Dynamics of Fluctuating Noncovalent DNA−Protein Interactions in DNA Damage Recognition

, 2016
Single-Molecule Conformational Dynamics of Fluctuating Noncovalent DNA−Protein Interactions in DNA Damage ...
Lilia M. Iakoucheva (13498), Eric J. Ackerman (2984313), H. Peter Lu (380336)   +2 more
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Protocol for measuring β-arrestin1-phosphorylated peptide interaction and analyzing conformational dynamics of β-arrestin1

STAR Protocols
Summary: Arrestins associate with phosphorylated G protein-coupled receptors and undergo conformational changes. Here, we present a protocol for measuring β-arrestin1-phosphorylated peptide interaction and analyzing conformational dynamics of β-arrestin1.
Kiae Kim, Ka Young Chung
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Helicity Induction and Conformational Dynamics of Poly(bis(4-carboxyphenoxy)phosphazene) with Optically Active Amines

, 2016
Helicity Induction and Conformational Dynamics of Poly(bis(4-carboxyphenoxy)phosphazene) with Optically Active ...
Eiji Yashima (1569460), Katsuhiro Maeda (1569451), Toshio Yamanaka (2205901)   +2 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Schematic illustration of the conformational dynamics of the complex with temporal charge redistributions.

, 2015
Schematic illustration of the conformational dynamics of the complex with temporal charge redistributions.
Vladimír Kopecký Jr. (731742), Pierre-Yves Turpin (731743), Bernard Alpert (731744), Josef Štěpánek (731741), Zhenlin Li (497813), Christian Zentz (731745)   +5 more
core   +1 more source

Ligand-coupled conformational changes in a cyclic nucleotide-gated ion channel revealed by time-resolved transition metal ion FRET

eLife
Cyclic nucleotide-binding domain (CNBD) ion channels play crucial roles in cellular-signaling and excitability and are regulated by the direct binding of cyclic adenosine- or guanosine-monophosphate (cAMP, cGMP). However, the precise allosteric mechanism
Pierce Eggan, Sharona E Gordon, William N Zagotta   +2 more
doaj   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Quantification of conformational changes at intra- and inter-dimer interfaces in molecular dynamics simulations.

, 2019
Quantification of conformational changes at intra- and inter-dimer interfaces in molecular dynamics simulations.
Fazoil I. Ataullakhanov (7330250), Nikita B. Gudimchuk (7330253), Philipp S. Orekhov (7330244), Ekaterina G. Kholina (5051114), Ilya B. Kovalenko (5051117), Vladimir A. Fedorov (7330241), Artem A. Zhmurov (7330247)   +6 more
core   +1 more source