ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Statistical accuracy of molecular dynamics-based methods for sampling conformational ensembles of disordered proteins [PDF]
The characterization of the statistical ensemble of conformations of Intrinsically Disordered Regions (IDRs) is a great challenge both from the experimental and com- putational points of view.
Federico, Fogolari +3 more
core +2 more sources
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Antagonist binding and induced conformational dynamics of GPCR A2A adenosine receptor
, 2013 Antagonist binding and induced conformational dynamics of GPCR A2A adenosine ...
韩克利, 杨明俊, 庞雪芹
core
Development of a normal mode-based geometric simulation approach for investigating the intrinsic mobility of proteins [PDF]
, 2010 Specific functions of biological systems often require conformational transitions of macromolecules. Thus, being able to describe and predict conformational changes of biological macromolecules is not only important for understanding their impact on ...
Ahmed, Aqeel
core
QEBSS: Quality Evaluation Based Simulation Selection for analysis of conformational ensembles and dynamics of multidomain proteins [PDF]
Multi-domain proteins, comprising both folded and intrinsically disordered regions, play pivotal roles in various biological processes, yet characterizing their conformational ensembles and dynamics presents significant challenges.
Amanda, Sandelin +3 more
core +2 more sources
Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations
Advanced ScienceADAM10 is a crucial membrane‐bound metalloprotease that regulates cellular physiology by cleaving and releasing membrane‐anchored proteins, including adhesion molecules and growth factor precursors, thereby modulating cell signaling, adhesion, and ...
Adrien Schahl +7 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Substrate entering and product leaving trajectories predict an engulfing dynamic for the major conformational change of the β-lactam acylase [PDF]
, 2008 It is still a major challenge to acquire insight into the conformational changes between the ground state and the transition state of an enzyme, although conformational fluctuation within interconverting conformers has been widely investigated (1-4 ...
Xi Huang +4 more
core
Alternate conformational trajectories in ribosome translocation.
PLoS Computational BiologyTranslocation in protein synthesis entails the efficient and accurate movement of the mRNA-[tRNA]2 substrate through the ribosome after peptide bond formation.
Jose L Alejo +6 more
doaj +1 more source