Results 81 to 90 of about 3,454,137 (301)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Three hydrolases and a transferase: comparative analysis of active-site dynamics via the BioSimGrid database [PDF]

, 2007
Comparative molecular dynamics (MD) simulations enable us to explore the conformational dynamics of the active sites of distantly related enzymes.
Baaden, Marc, Muan Hong Ngd, Essex, Jonathan, Sansom, MS, Sansom, Mark, Murdock, S, Cox, K, Cox, Katherine, Tai, K, Ng, Muan Hong, Tai, Kaihsu, Jonathan W. Essexc, Steven Johnstonc, Bing Wua, Marc Baadenb, Essex, Jonathan W, Baaden, M, Essex, JW, Essex, Jonathan W., Sansom, Mark S.P., Murdock, Stuart, Wu, Bing, Stuart Murdockc, Johnston, Steven, Fangohr, Hans, Wu, B, Kaihsu Taia, Richard Boardmanc, Ng, MH, Boardman, R, Fangohr, H, Mark S. P. Sansoma, Katherine Coxa, Sansom, Mark S. P., Johnston, S, Hans Fangohrd, Boardman, Richard   +36 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Linking time-series of single-molecule experiments with molecular dynamics simulations by machine learning

eLife, 2018
Single-molecule experiments and molecular dynamics (MD) simulations are indispensable tools for investigating protein conformational dynamics. The former provide time-series data, such as donor-acceptor distances, whereas the latter give atomistic ...
Yasuhiro Matsunaga, Yuji Sugita
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Conformal invariance and critical dynamics

Journal of Physics A: Mathematical and General, 1985
The author discusses the behaviour of dynamic correlation functions under conformal transformations. In particular the exact form of the dynamic scaling function at the critical point for an arbitrary isotropic two-dimensional model is obtained with either conserved or nonconserved order parameter.
openaire   +2 more sources

Pulsed Dipolar EPR for Self-Limited Complexes of Oligonucleotides Studies

Biomolecules
Pulsed electron–electron double resonance (PELDOR) spectroscopy is a powerful method for determining nucleic acid (NA) structure and conformational dynamics.
Alexey S. Chubarov, Burkhard Endeward, Maria A. Kanarskaya, Yuliya F. Polienko, Thomas F. Prisner, Alexander A. Lomzov   +5 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Loop dynamics govern MALT1 activation revealed by integrative AlphaFold, MD, and NMR analysis

Scientific Reports
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a central regulator of immune signalling, yet how its conformational dynamics govern activation remains poorly understood.
Dmitry Lesovoy, Tatiana Agback, Konstantin Roshchin, Tatyana Sandalova, Adnane Achour, Xiao Han, Alexander Lomzov, Vladislav Orekhov, Peter Agback   +8 more
doaj   +1 more source