Results 81 to 90 of about 3,449,175 (207)

Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations

Advanced Science
ADAM10 is a crucial membrane‐bound metalloprotease that regulates cellular physiology by cleaving and releasing membrane‐anchored proteins, including adhesion molecules and growth factor precursors, thereby modulating cell signaling, adhesion, and ...
Adrien Schahl, Nandan Haloi, Marta Carroni, Shengpan Zhang, Quentin James Sattentau, Erdinc Sezgin, Lucie Delemotte, Rebecca J. Howard   +7 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Statistical accuracy of molecular dynamics-based methods for sampling conformational ensembles of disordered proteins [PDF]

The characterization of the statistical ensemble of conformations of Intrinsically Disordered Regions (IDRs) is a great challenge both from the experimental and com- putational points of view.
Federico, Fogolari, Miguel A., Soler, José, Zúñiga, Adolfo, Bastida   +3 more
core   +2 more sources

Alternate conformational trajectories in ribosome translocation.

PLoS Computational Biology
Translocation in protein synthesis entails the efficient and accurate movement of the mRNA-[tRNA]2 substrate through the ribosome after peptide bond formation.
Jose L Alejo, Dylan Girodat, Michael J Hammerling, Jessica A Willi, Michael C Jewett, Aaron E Engelhart, Katarzyna P Adamala   +6 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Global Conformational Dynamics in Ras

, 2016
Ras and its homologues are central to regulation of a multitude of cellular processes. Ras in complex with GTP binds and activates its downstream signaling partners.
Evgenii L. Kovrigin (591128), Casey O’Connor (2017444)   +1 more
core   +1 more source

Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor

eLife, 2019
Metabotropic glutamate receptors (mGluRs) are class C, synaptic G-protein-coupled receptors (GPCRs) that contain large extracellular ligand binding domains (LBDs) and form constitutive dimers.
Vanessa A Gutzeit, Jordana Thibado, Daniel Starer Stor, Zhou Zhou, Scott C Blanchard, Olaf S Andersen, Joshua Levitz   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Dynamics of conformational relaxation in photoexcited oligofluorenes and polyfluorene

, 2006
In order to disentangle the relaxation effects of exciton migration and conformational rearrangement, a comparative study of a polyfluorene derivative and short oligofluorenes is carried out.
Hintschich, SI, Monkman, AP, Dias, FB
core   +1 more source