Results 131 to 140 of about 3,678,372 (337)

Dynamics of conformal foliations [PDF]

Applied Mathematics and Nonlinear Sciences, 2020
Abstract The purpose of this article is to review the author's results on the existence and structure of minimal sets and attractors of conformal foliations. Results on strong transversal equivalence of conformal foliations are also presented. Connections with works of other authors are indicated.
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Analysis of AlphaFold and molecular dynamics structure predictions of mutations in serpins.

PLoS ONE
Serine protease inhibitors (serpins) include thousands of structurally conserved proteins playing key roles in many organisms. Mutations affecting serpins may disturb their conformation, leading to inactive forms.
Pedro Garrido-Rodríguez, Miguel Carmena-Bargueño, María Eugenia de la Morena-Barrio, Carlos Bravo-Pérez, Belén de la Morena-Barrio, Rosa Cifuentes-Riquelme, María Luisa Lozano, Horacio Pérez-Sánchez, Javier Corral   +8 more
doaj   +1 more source

Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. [PDF]

, 2019
We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational ...
Chang, Geoffrey, Komives, Elizabeth A, Kopcho, Noah   +2 more
core   +1 more source

The role of conformational diffusion in ion channel gating

, 2003
We consider an exactly tractable model of the Kramers type for the voltage-dependent gating dynamics of single ion channels. It is assumed that the gating dynamics is caused by the thermally activated transitions in a bistable potential.
Bezanilla, Blatz, Bässler, Colquhoun, Condat, de Gennes, Dobson, Frauenfelder, Frauenfelder, Goychuk, Hille, Hodgkin, Hänggi, Igor Goychuk, Jiang, Liebovitch, Läuger, Mainen, Mercik, Metzler, Millhauser, Moore, Peter Hänggi, Ring, Rodriguez, Salman, Sansom, Sigg, Yellen   +28 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Alternate conformational trajectories in ribosome translocation.

PLoS Computational Biology
Translocation in protein synthesis entails the efficient and accurate movement of the mRNA-[tRNA]2 substrate through the ribosome after peptide bond formation.
Jose L Alejo, Dylan Girodat, Michael J Hammerling, Jessica A Willi, Michael C Jewett, Aaron E Engelhart, Katarzyna P Adamala   +6 more
doaj   +1 more source

High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics

Cell Reports, 2018
Summary: Fluorescent labels offer the capability to follow conformational dynamics of membrane proteins, but signal detection in such recordings is inherently difficult to achieve in a cell membrane and lacks sufficient time resolution to follow ...
Matthias Wulf, Stephan Alexander Pless
doaj   +1 more source

Conformal invariance and critical dynamics

Journal of Physics A: Mathematical and General, 1985
The author discusses the behaviour of dynamic correlation functions under conformal transformations. In particular the exact form of the dynamic scaling function at the critical point for an arbitrary isotropic two-dimensional model is obtained with either conserved or nonconserved order parameter.
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source